Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp4v3provided by RGD
Official Full Name: cytochrome P450, family 4, subfamily v, polypeptide 3provided by RGD
Primary source: RGD:708530
See related: Ensembl:ENSRNOG00000042426 AllianceGenome:RGD:708530
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp4v2
Summary: Predicted to enable heme binding activity; iron ion binding activity; and long-chain fatty acid omega-hydroxylase activity. Predicted to be involved in fatty acid omega-oxidation. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 84.7), Liver (RPKM 76.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (53650978..53675916)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (46917929..46958735)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (50111803..50136741)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue kallikrein mRNA expression is increased during prenatal and early postnatal development stages in rat brain.
Title: Expression of tissue kallikrein mRNA in developing rat brains.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131514 (e-PCR)
- UniSTS:214797

RH131038 (e-PCR)
- UniSTS:214321

RH132699 (e-PCR)
- UniSTS:215982

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-hydroxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid omega-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid omega-oxidation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome P450 4V2

Names: cytochrome P450 4V3; cytochrome P450-like protein; docosahexaenoic acid omega-hydroxylase CYP4V2; long-chain fatty acid omega-monooxygenase

NP_001129072.1

EC 1.14.14.79

EC 1.14.14.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.