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    Tiprl TOR signaling pathway regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360869, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tiprlprovided by RGD
    Official Full Name
    TOR signaling pathway regulatorprovided by RGD
    Primary source
    RGD:1310442
    See related
    Ensembl:ENSRNOG00000003048 AllianceGenome:RGD:1310442
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310442
    Summary
    Predicted to be involved in DNA damage checkpoint signaling; TOR signaling; and negative regulation of phosphoprotein phosphatase activity. Predicted to be active in cytosol. Orthologous to human TIPRL (TOR signaling pathway regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 132.7), Brain (RPKM 127.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tiprl in Genome Data Viewer
    Location:
    13q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80060193..80085040, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77527176..77552026, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83478966..83504448, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 19 Neighboring gene SFT2 domain containing 2 Neighboring gene G protein-coupled receptor 161 Neighboring gene DDB1 and CUL4 associated factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. McConnell JL, et al. Oncogene, 2007 Sep 6. PMID 17384681
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TIP41-like protein
    Names
    CG9578-like
    TIP41, TOR signaling pathway regulator-like
    TIP41, TOR signalling pathway regulator-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109667.1 → NP_001103137.1  TIP41-like protein

      See identical proteins and their annotated locations for NP_001103137.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128780
      UniProtKB/Swiss-Prot
      A2VCX1
      UniProtKB/TrEMBL
      A0A8L2Q0M7
      Related
      ENSRNOP00000004083.6, ENSRNOT00000004083.7
      Conserved Domains (1) summary
      pfam04176
      Location:50 → 218
      TIP41; TIP41-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80060193..80085040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090912.2 → XP_038946840.1  TIP41-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKG4
      Conserved Domains (1) summary
      pfam04176
      Location:9 → 177
      TIP41; TIP41-like family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VCX1.1 GenPept UniProtKB/Swiss-Prot:A2VCX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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