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    Zfp709 zinc finger protein 709 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266773, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp709provided by RGD
    Official Full Name
    zinc finger protein 709provided by RGD
    Primary source
    RGD:628698
    See related
    Ensembl:ENSRNOG00000016186 AllianceGenome:RGD:628698
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hit40; Znf14
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to heat and cellular response to lipopolysaccharide. Located in plasma membrane. Orthologous to human ZNF443 (zinc finger protein 443). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 83.0), Muscle (RPKM 38.7) and 9 other tissues See more
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    Genomic context

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    See Zfp709 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17942986..17953720, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17907599..17920047, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19632954..19643956, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 617 Neighboring gene uncharacterized LOC102548752 Neighboring gene uncharacterized LOC134482464 Neighboring gene zinc finger protein 878 Neighboring gene HAUS augmin-like complex, subunit 8 Neighboring gene myosin IXb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heat stress modulates hepatocyte membrane proteins during endotoxemia. Przkora R, et al. Burns, 2007 Aug. PMID 17374454
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 14
    Names
    zinc finger protein 14 (KOX 6)
    zinc finger protein HIT-40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153731.1 → NP_714953.1  zinc finger protein 14

      See identical proteins and their annotated locations for NP_714953.1

      Status: PROVISIONAL

      Source sequence(s)
      AF277903
      UniProtKB/TrEMBL
      Q99PJ6
      Conserved Domains (5) summary
      smart00349
      Location:11 → 51
      KRAB; krueppel associated box
      COG5048
      Location:259 → 701
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:431 → 451
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:11 → 50
      KRAB; KRAB box
      pfam13465
      Location:303 → 328
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      17942986..17953720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252841.5 → XP_006252903.1  zinc finger protein 14 isoform X2

      See identical proteins and their annotated locations for XP_006252903.1

      UniProtKB/TrEMBL
      A0A0G2KAB4
      Related
      ENSRNOP00000075334.2
      Conserved Domains (5) summary
      smart00349
      Location:25 → 65
      KRAB; krueppel associated box
      COG5048
      Location:273 → 715
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:445 → 465
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:25 → 64
      KRAB; KRAB box
      pfam13465
      Location:317 → 342
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006252840.5 → XP_006252902.1  zinc finger protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHX4
      Related
      ENSRNOP00000093615.1
      Conserved Domains (5) summary
      smart00349
      Location:40 → 80
      KRAB; krueppel associated box
      COG5048
      Location:288 → 730
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:460 → 480
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:40 → 79
      KRAB; KRAB box
      pfam13465
      Location:332 → 357
      zf-H2C2_2; Zinc-finger double domain

    3. XM_039094244.2 → XP_038950172.1  zinc finger protein 14 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:220 → 662
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_008771070.4 → XP_008769292.1  zinc finger protein 14 isoform X3

      See identical proteins and their annotated locations for XP_008769292.1

      Related
      ENSRNOP00000079050.1
      Conserved Domains (2) summary
      COG5048
      Location:220 → 662
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_008771069.4 → XP_008769291.1  zinc finger protein 14 isoform X3

      See identical proteins and their annotated locations for XP_008769291.1

      Conserved Domains (2) summary
      COG5048
      Location:220 → 662
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_008771072.4 → XP_008769294.1  zinc finger protein 14 isoform X4

      Conserved Domains (3) summary
      COG5048
      Location:141 → 583
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:313 → 333
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:185 → 210
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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