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    Zfp746 zinc finger protein 746 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312303, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Zfp746provided by RGD
    Official Full Name
    zinc finger protein 746provided by RGD
    Primary source
    RGD:1306209
    See related
    Ensembl:ENSRNOG00000007064 AllianceGenome:RGD:1306209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf746; RGD1306209
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of neuron death; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Orthologous to human ZNF746 (zinc finger protein 746). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 79.8), Spleen (RPKM 53.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp746 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (78385945..78410240, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77055008..77078968, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (77723182..77747511, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) 1 Neighboring gene zinc finger protein 777 Neighboring gene transfer RNA cysteine (anticodon GCA) 2 Neighboring gene transfer RNA cysteine (anticodon GCA) 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Shin JH, et al. Cell, 2011 Mar 4. PMID 21376232, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 746

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100852.1 → NP_001094322.1  zinc finger protein 746

      See identical proteins and their annotated locations for NP_001094322.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AAQ7, F1LSG4
      Related
      ENSRNOP00000009247.4, ENSRNOT00000009247.6
      Conserved Domains (6) summary
      smart00349
      Location:107 → 156
      KRAB; krueppel associated box
      COG5048
      Location:516 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:571 → 593
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:558 → 582
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      78385945..78410240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107551.2 → XP_038963479.1  zinc finger protein 746 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AAQ7
      Related
      ENSRNOP00000076748.1
      Conserved Domains (6) summary
      smart00349
      Location:107 → 156
      KRAB; krueppel associated box
      COG5048
      Location:473 → 551
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:474 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:528 → 550
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:515 → 539
      zf-H2C2_2; Zinc-finger double domain

    2. XM_063286027.1 → XP_063142097.1  zinc finger protein 746 isoform X7

      UniProtKB/TrEMBL
      A0A8I5YBV9, A0A8I6AAQ7

    3. XM_006236419.5 → XP_006236481.1  zinc finger protein 746 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AAQ7
      Conserved Domains (6) summary
      smart00349
      Location:107 → 156
      KRAB; krueppel associated box
      COG5048
      Location:515 → 593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:516 → 536
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:570 → 592
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:557 → 581
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039107550.2 → XP_038963478.1  zinc finger protein 746 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AAQ7
      Conserved Domains (6) summary
      smart00349
      Location:113 → 162
      KRAB; krueppel associated box
      COG5048
      Location:479 → 557
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:534 → 556
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:31 → 87
      DUF3669; Zinc finger protein
      pfam13465
      Location:521 → 545
      zf-H2C2_2; Zinc-finger double domain

    5. XM_039107549.2 → XP_038963477.1  zinc finger protein 746 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AAQ7
      Conserved Domains (6) summary
      smart00349
      Location:113 → 162
      KRAB; krueppel associated box
      COG5048
      Location:480 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:481 → 501
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:535 → 557
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:31 → 87
      DUF3669; Zinc finger protein
      pfam13465
      Location:522 → 546
      zf-H2C2_2; Zinc-finger double domain

    6. XM_039107548.2 → XP_038963476.1  zinc finger protein 746 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAQ7
      Conserved Domains (6) summary
      COG5048
      Location:484 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:485 → 505
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:539 → 561
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:31 → 87
      DUF3669; Zinc finger protein
      pfam13465
      Location:526 → 550
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:113 → 163
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    7. XM_039107547.2 → XP_038963475.1  zinc finger protein 746 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AAQ7
      Conserved Domains (6) summary
      smart00349
      Location:113 → 162
      KRAB; krueppel associated box
      COG5048
      Location:521 → 599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:522 → 542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:576 → 598
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:31 → 87
      DUF3669; Zinc finger protein
      pfam13465
      Location:563 → 587
      zf-H2C2_2; Zinc-finger double domain

    8. XM_008762887.4 → XP_008761109.1  zinc finger protein 746 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAQ7
      Conserved Domains (6) summary
      cd07765
      Location:114 → 141
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:113 → 162
      KRAB; krueppel associated box
      COG5048
      Location:522 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:577 → 599
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:535 → 559
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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