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    Baz1b bromodomain adjacent to zinc finger domain, 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 368002, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Baz1bprovided by RGD
    Official Full Name
    bromodomain adjacent to zinc finger domain, 1Bprovided by RGD
    Primary source
    RGD:1597089
    See related
    Ensembl:ENSRNOG00000001453 AllianceGenome:RGD:1597089
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone binding activity; histone kinase activity; and protein tyrosine kinase activity. Predicted to be involved in cellular response to DNA damage stimulus and histone phosphorylation. Predicted to act upstream of or within chromatin assembly or disassembly and chromatin remodeling. Predicted to be located in condensed chromosome; nuclear body; and pericentric heterochromatin. Predicted to colocalize with nuclear replication fork. Orthologous to human BAZ1B (bromodomain adjacent to zinc finger domain 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 256.0), Thymus (RPKM 247.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Baz1b in Genome Data Viewer
    Location:
    12q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (27068541..27126511, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21431985..21489956, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24478882..24536851, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481280 Neighboring gene frizzled class receptor 9 Neighboring gene 5S ribosomal RNA Neighboring gene BAF chromatin remodeling complex subunit BCL7B Neighboring gene transducin (beta)-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci. Poot RA, et al. Nat Cell Biol, 2004 Dec. PMID 15543136
    2. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Xiao A, et al. Nature, 2009 Jan 1. PMID 19092802, Free PMC Article
    3. WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. Bozhenok L, et al. EMBO J, 2002 May 1. PMID 11980720, Free PMC Article
    4. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S, et al. Nat Rev Mol Cell Biol, 2013 Oct. PMID 24002223
    5. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Hargreaves DC, et al. Cell Res, 2011 Mar. PMID 21358755, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of B-WICH complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of WICH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of WICH complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase BAZ1B
    Names
    bromodomain adjacent to zinc finger domain protein 1B
    NP_001178845.1
    XP_038945581.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191916.1 → NP_001178845.1  tyrosine-protein kinase BAZ1B

      See identical proteins and their annotated locations for NP_001178845.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6ALC2, A6J0E2, G3V661
      Related
      ENSRNOP00000094596.1, ENSRNOT00000100108.1
      Conserved Domains (7) summary
      cd05505
      Location:1337 → 1433
      Bromo_WSTF_like; Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two ...
      smart00571
      Location:602 → 666
      DDT; domain in different transcription and chromosome remodeling factors
      cd15628
      Location:1183 → 1228
      PHD_BAZ1B; PHD finger found in bromodomain adjacent to zinc finger domain protein 1B (BAZ1B)
      pfam10537
      Location:21 → 120
      WAC_Acf1_DNA_bd; ATP-utilizing chromatin assembly and remodelling N-terminal
      pfam15612
      Location:722 → 771
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:897 → 925
      WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
      pfam15614
      Location:988 → 1026
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      27068541..27126511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089653.2 → XP_038945581.1  tyrosine-protein kinase BAZ1B isoform X1

      UniProtKB/TrEMBL
      G3V661
      Conserved Domains (7) summary
      cd05505
      Location:1040 → 1136
      Bromo_WSTF_like; Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two ...
      smart00571
      Location:305 → 369
      DDT; domain in different transcription and chromosome remodeling factors
      cd15628
      Location:886 → 931
      PHD_BAZ1B; PHD finger found in bromodomain adjacent to zinc finger domain protein 1B (BAZ1B)
      pfam17380
      Location:464 → 562
      DUF5401; Family of unknown function (DUF5401)
      pfam15612
      Location:428 → 468
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:599 → 725
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam15709
      Location:210 → 270
      DUF4670; Domain of unknown function (DUF4670)
    Nucleotide Protein Strain
    Heading Accession and Version

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