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    RAPGEF5 Rap guanine nucleotide exchange factor 5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 711698, updated on 5-Mar-2024

    Summary

    Official Symbol
    RAPGEF5provided by VGNC
    Official Full Name
    Rap guanine nucleotide exchange factor 5provided by VGNC
    Primary source
    VGNC:VGNC:76494
    See related
    Ensembl:ENSMMUG00000002987
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
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    Genomic context

    See RAPGEF5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (92693594..92936892)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (85867163..86111414)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114676967 Neighboring gene uncharacterized LOC106997496 Neighboring gene uncharacterized LOC114676968 Neighboring gene cell division cycle associated 7 like Neighboring gene dynein axonemal heavy chain 11

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 5
    Names
    Rap guanine nucleotide exchange factor (GEF) 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001194158.3NP_001181087.1  rap guanine nucleotide exchange factor 5

      See identical proteins and their annotated locations for NP_001181087.1

      Status: PROVISIONAL

      Source sequence(s)
      QNVO02000313
      UniProtKB/TrEMBL
      A0A1D5Q995, H9G2F6
      Related
      ENSMMUP00000044613.2, ENSMMUT00000068824.2
      Conserved Domains (3) summary
      smart00147
      Location:491730
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:219350
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl02442
      Location:172
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      92693594..92936892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015133876.2XP_014989362.2  rap guanine nucleotide exchange factor 5 isoform X1

      UniProtKB/TrEMBL
      F6WAW0, F7GVW4
      Related
      ENSMMUP00000035150.3, ENSMMUT00000042151.3
      Conserved Domains (3) summary
      smart00147
      Location:644883
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:372503
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:103225
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    2. XM_028844993.1XP_028700826.1  rap guanine nucleotide exchange factor 5 isoform X3

      UniProtKB/TrEMBL
      F7GVW4
      Conserved Domains (3) summary
      smart00147
      Location:547786
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:275406
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl02442
      Location:103130
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
    3. XM_028844992.1XP_028700825.1  rap guanine nucleotide exchange factor 5 isoform X2

      UniProtKB/TrEMBL
      F7GVX4
      Related
      ENSMMUP00000003993.4, ENSMMUT00000004233.4
      Conserved Domains (3) summary
      smart00147
      Location:594833
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:322453
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:53175
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...