U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rict-1 RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565035, updated on 12-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    rict-1
    Gene description
    RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein
    Locus tag
    CELE_F29C12.3
    See related
    AllianceGenome:WB:WBGene00009245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Involved in mesendoderm development. Part of TORC2 complex. Is expressed in several structures, including head neurons; intestine; pharynx; spermatheca; and ventral nerve cord. Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rict-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (13098239..13116810, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene DUF3444 domain-containing protein Neighboring gene Eukaryotic translation initiation factor 2-alpha kinase gcn-2 Neighboring gene DUF19 domain-containing protein Neighboring gene Collagen triple helix repeat protein;Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene Elongation factor G, mitochondrial Neighboring gene BTB and MATH domain-containing protein 45

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans. Aspernig H, et al. Cell Rep, 2019 Nov 5. PMID 31693882
    2. Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. O'Donnell MP, et al. PLoS Genet, 2018 Feb. PMID 29415022, Free PMC Article
    3. mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity. Mizunuma M, et al. Aging Cell, 2014 Oct. PMID 25040785, Free PMC Article
    4. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. Yen K, et al. PLoS One, 2010 Sep 16. PMID 20862331, Free PMC Article
    5. The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans. Sakai N, et al. PLoS One, 2017. PMID 28542414, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mesendoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TORC2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein
    NP_001254376.1
    • Confirmed by transcript evidence
    NP_001254377.1
    • Confirmed by transcript evidence
    NP_001254378.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13098239..13116810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267447.2 → NP_001254376.1  RICTOR_N domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254376.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFK2
      Conserved Domains (4) summary
      pfam14663
      Location:890 → 991
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:94 → 499
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14666
      Location:783 → 883
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:1055 → 1121
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    2. NM_001267448.2 → NP_001254377.1  RICTOR_N domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFN2
      Conserved Domains (4) summary
      pfam14663
      Location:892 → 993
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:94 → 501
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14666
      Location:785 → 885
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:1057 → 1123
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    3. NM_001267449.3 → NP_001254378.1  Rapamycin-insensitive companion of mTOR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254378.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED67
      Conserved Domains (3) summary
      pfam14663
      Location:80 → 181
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14666
      Location:2 → 73
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:245 → 311
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.