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    F08H9.3 SHSP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 184214, updated on 12-Jun-2024

    Summary

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    Gene symbol
    F08H9.3
    Gene description
    SHSP domain-containing protein
    Locus tag
    CELE_F08H9.3
    See related
    AllianceGenome:WB:WBGene00008591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Is expressed in intestinal cell and pharynx. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B) and HSPB6 (heat shock protein family B (small) member 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See F08H9.3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (14461947..14463338, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein Neighboring gene SPerm CHromatin enriched Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SHSP domain-containing protein Neighboring gene Serpentine Receptor, class Z Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SHSP domain-containing protein
    NP_506585.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14461947..14463338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074184.4 → NP_506585.1  SHSP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19227
      Conserved Domains (1) summary
      cd06526
      Location:43 → 125
      metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    Nucleotide Protein
    Heading Accession and Version

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