Cluh clustered mitochondria homolog [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cluhprovided by MGI
Official Full Name: clustered mitochondria homologprovided by MGI
Primary source: MGI:MGI:1921398
See related: Ensembl:ENSMUSG00000020741 AllianceGenome:MGI:1921398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kiaa0664; mKIAA0664; 1300001I01Rik
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in intracellular distribution of mitochondria. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; naris; pectoral girdle and thoracic body wall musculature; and renal calyx. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 48.6), adrenal adult (RPKM 47.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.76 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (74539707..74561680)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (74648881..74670854)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
Title: Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
Title: Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy.
Title: CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:236635 (e-PCR)
- UniSTS:236635

RH129368 (e-PCR)
- UniSTS:212675

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular distribution of mitochondria	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in organelle organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: clustered mitochondria protein homolog

Names: clustered mitochondria (cluA/CLU1) homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081158.3 → NP_001074627.1 clustered mitochondria protein homolog isoform 1

See identical proteins and their annotated locations for NP_001074627.1

Status: VALIDATED

Source sequence(s)

AL607024, AL645971

Consensus CDS

CCDS36223.1

UniProtKB/TrEMBL

A0A0R4J140, Z4YLI8

Related

ENSMUSP00000090593.6, ENSMUST00000092915.12

Conserved Domains (6) summary

sd00006
Location:1062 → 1088

TPR; TPR repeat [structural motif]

pfam12807
Location:809 → 988

eIF3_p135; Translation initiation factor eIF3 subunit 135

pfam13236
Location:394 → 614

CLU; Clustered mitochondria

pfam13374
Location:1061 → 1100

TPR_10; Tetratricopeptide repeat

pfam13424
Location:1140 → 1217

TPR_12; Tetratricopeptide repeat

pfam15044
Location:104 → 177

CLU_N; Mitochondrial function, CLU-N-term
NM_001368711.1 → NP_001355640.1 clustered mitochondria protein homolog isoform 2

Status: VALIDATED

Source sequence(s)

AL607024, AL645971

UniProtKB/Swiss-Prot

A8Y5E2, Q3U014, Q3U4M5, Q3V3Q8, Q505Q6, Q5SW19, Q6GQX1, Q6PAT1, Q8CHD9

UniProtKB/TrEMBL

Z4YLI8

Conserved Domains (5) summary

sd00006
Location:1024 → 1050

TPR; TPR repeat [structural motif]

pfam13424
Location:1104 → 1179

TPR_12; Tetratricopeptide repeat

pfam12807
Location:769 → 950

eIF3_p135; Translation initiation factor eIF3 subunit 135

pfam13236
Location:356 → 576

CLU; Clustered mitochondria

pfam15044
Location:66 → 139

CLU_N; Mitochondrial function, CLU-N-term

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

74539707..74561680

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314805.3 → XP_017170294.1 clustered mitochondria protein homolog isoform X1

UniProtKB/TrEMBL

Z4YLI8

Conserved Domains (5) summary

sd00006
Location:1061 → 1087

TPR; TPR repeat [structural motif]

pfam13424
Location:1141 → 1216

TPR_12; Tetratricopeptide repeat

pfam12807
Location:806 → 987

eIF3_p135; Translation initiation factor eIF3 subunit 135

pfam13236
Location:394 → 614

CLU; Clustered mitochondria

pfam15044
Location:104 → 177

CLU_N; Mitochondrial function, CLU-N-term
XM_006534353.4 → XP_006534416.1 clustered mitochondria protein homolog isoform X2

See identical proteins and their annotated locations for XP_006534416.1

UniProtKB/Swiss-Prot

A8Y5E2, Q3U014, Q3U4M5, Q3V3Q8, Q505Q6, Q5SW19, Q6GQX1, Q6PAT1, Q8CHD9

UniProtKB/TrEMBL

Z4YLI8

Conserved Domains (5) summary

sd00006
Location:1024 → 1050

TPR; TPR repeat [structural motif]

pfam13424
Location:1104 → 1179

TPR_12; Tetratricopeptide repeat

pfam12807
Location:769 → 950

eIF3_p135; Translation initiation factor eIF3 subunit 135

pfam13236
Location:356 → 576

CLU; Clustered mitochondria

pfam15044
Location:66 → 139

CLU_N; Mitochondrial function, CLU-N-term