hbaa1 hemoglobin, alpha adult 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hbaa1provided by ZNC
Official Full Name: hemoglobin, alpha adult 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-79
See related: Ensembl:ENSDARG00000097011 AllianceGenome:ZFIN:ZDB-GENE-980526-79
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: AA1; hbaa1.1; dZ118J2.2
Summary: Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within response to hypoxia. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in eye; hematopoietic system; presumptive blood; and vasculature. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBZ (hemoglobin subunit zeta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (55100112..55100933)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (54845510..54846331)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Joint locus of alpha/beta-globin genes in Danio rerio is segregated into structural subdomains active at different stages of development.
Title: [Joint locus of a/b-globin genes in Danio rerio is segregated into structural subdomains active at different stages of development].

Submit: New GeneRIF Correction

General gene information

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Markers

hba1 (e-PCR)
- UniSTS:186966

U50380 (e-PCR)
- UniSTS:205677

fj04a05.x1 (e-PCR)
- UniSTS:198337

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to haptoglobin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables organic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info
contributes_to peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oxygen transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of haptoglobin-hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hemoglobin subunit alpha

Names: alpha-globin aa1; hemoglobin alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131257.3 → NP_571332.3 hemoglobin subunit alpha

Status: VALIDATED

Source sequence(s)

AL935210

UniProtKB/Swiss-Prot

Q90487

UniProtKB/TrEMBL

E7F4I1, Q1JQ69, Q803Z5

Related

ENSDARP00000101541.3, ENSDART00000113098.5

Conserved Domains (1) summary

cd08927
Location:3 → 143

Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits