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    usp2a ubiquitin specific peptidase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 494031, updated on 25-Apr-2024

    Summary

    Official Symbol
    usp2aprovided by ZNC
    Official Full Name
    ubiquitin specific peptidase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-59
    See related
    Ensembl:ENSDARG00000020107 AllianceGenome:ZFIN:ZDB-GENE-041212-59
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92134
    Summary
    Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human USP2 (ubiquitin specific peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See usp2a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20900627..20939599, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20964895..21003867, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene unc-51 like autophagy activating kinase 2 Neighboring gene GTPase IMAP family member 4-like Neighboring gene tubulin folding cofactor E-like a Neighboring gene alpha-2-macroglobulin-like protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 2; ubiquitin carboxyl-terminal hydrolase 2a
    NP_001008574.2
    XP_005157570.1
    XP_005157571.1
    XP_005157572.1
    XP_005157573.1
    XP_017206440.1
    XP_021337071.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008574.2NP_001008574.2  ubiquitin carboxyl-terminal hydrolase 2a

      Status: VALIDATED

      Source sequence(s)
      BX548078
      UniProtKB/TrEMBL
      A0A8M1N3I7, F1R2P1
      Related
      ENSDARP00000119800.1, ENSDART00000134053.4

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      20900627..20939599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157514.4XP_005157571.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

      See identical proteins and their annotated locations for XP_005157571.1

      UniProtKB/TrEMBL
      A0A8M9QLD6
      Conserved Domains (1) summary
      pfam00443
      Location:230559
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. XM_021481396.1XP_021337071.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLD6
      Conserved Domains (1) summary
      pfam00443
      Location:230559
      UCH; Ubiquitin carboxyl-terminal hydrolase
    3. XM_005157513.4XP_005157570.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

      See identical proteins and their annotated locations for XP_005157570.1

      UniProtKB/TrEMBL
      A0A8M9QLD6
      Conserved Domains (1) summary
      pfam00443
      Location:230559
      UCH; Ubiquitin carboxyl-terminal hydrolase
    4. XM_005157515.4XP_005157572.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B4B5
      Conserved Domains (2) summary
      cd02674
      Location:231559
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:229558
      UCH; Ubiquitin carboxyl-terminal hydrolase
    5. XM_017350951.2XP_017206440.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLD6
      Conserved Domains (1) summary
      pfam00443
      Location:230559
      UCH; Ubiquitin carboxyl-terminal hydrolase
    6. XM_005157516.4XP_005157573.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B3N0
      Conserved Domains (2) summary
      cd02674
      Location:62391
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:60390
      UCH; Ubiquitin carboxyl-terminal hydrolase