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    mgat1a alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase a [ Danio rerio (zebrafish) ]

    Gene ID: 393649, updated on 27-Mar-2024

    Summary

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    Official Symbol
    mgat1aprovided by ZNC
    Official Full Name
    alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1515
    See related
    Ensembl:ENSDARG00000012407 AllianceGenome:ZFIN:ZDB-GENE-040426-1515
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66030
    Summary
    Predicted to enable alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mgat1a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34867515..34878358, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (35009546..35020389, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid (GABA) B receptor, 1a Neighboring gene SH3-binding domain protein 5-like, a Neighboring gene ring finger protein 183 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Erickson T, et al. Elife, 2017 May 23. PMID 28534737, Free PMC Article
    2. The zebrafish maternal-effect gene mission impossible encodes the DEAH-box helicase Dhx16 and is essential for the expression of downstream endodermal genes. Putiri E, et al. Dev Biol, 2011 May 15. PMID 21396359, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66030

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase a; alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
    Names
    mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase a
    NP_956970.1
    XP_005157814.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200676.1 → NP_956970.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase a

      See identical proteins and their annotated locations for NP_956970.1

      Status: PROVISIONAL

      Source sequence(s)
      BC058297
      UniProtKB/TrEMBL
      A0A8M1PBK2, Q6PE41
      Related
      ENSDARP00000155006.1, ENSDART00000191980.1
      Conserved Domains (1) summary
      cd02514
      Location:112 → 442
      GT13_GLCNAC-TI; GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      34867515..34878358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157757.3 → XP_005157814.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B420, F1QTA6
      Related
      ENSDARP00000128020.1, ENSDART00000154094.2
      Conserved Domains (1) summary
      cd02514
      Location:162 → 492
      GT13_GLCNAC-TI; GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides
    Nucleotide Protein
    Heading Accession and Version

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