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    cishb cytokine inducible SH2-containing protein b [ Danio rerio (zebrafish) ]

    Gene ID: 100136861, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cishbprovided by ZNC
    Official Full Name
    cytokine inducible SH2-containing protein bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-120
    See related
    Ensembl:ENSDARG00000016773 AllianceGenome:ZFIN:ZDB-GENE-080204-120
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    socs8; cish.b; zgc:175109
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within intracellular signal transduction; negative regulation of signal transduction; and regulation of growth. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See cishb in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (17959488..17964533, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (17824853..17829898, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886550 Neighboring gene uncharacterized LOC103911824 Neighboring gene twinfilin actin-binding protein 2b Neighboring gene RNA pseudouridine synthase D4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Long-term effects of ionizing radiation on gene expression in a zebrafish model. Jaafar L, et al. PLoS One, 2013. PMID 23936019, Free PMC Article
    2. Prolactin controls branchial clcn2c but not atp1a1a.2 in zebrafish Danio rerio. Breves JP. J Fish Biol, 2019 Jan. PMID 30367725
    3. Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin. Park J, et al. BMC Genomics, 2018 Oct 29. PMID 30373515, Free PMC Article
    4. Regulation of embryonic hematopoiesis by a cytokine-inducible SH2 domain homolog in zebrafish. Lewis RS, et al. J Immunol, 2014 Jun 15. PMID 24835394
    5. Global identification and comparative analysis of SOCS genes in fish: insights into the molecular evolution of SOCS family. Jin HJ, et al. Mol Immunol, 2008 Mar. PMID 18029016

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytokine inducible SH2-containing protein b
    Names
    suppressor of cytokine signaling 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114554.1 → NP_001108026.1  cytokine inducible SH2-containing protein b

      See identical proteins and their annotated locations for NP_001108026.1

      Status: PROVISIONAL

      Source sequence(s)
      EF195766
      UniProtKB/TrEMBL
      A9JRX2
      Conserved Domains (1) summary
      cd10718
      Location:42 → 129
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      17959488..17964533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358181.1 → XP_017213670.1  cytokine inducible SH2-containing protein b isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1L6, L0N8L8
      Related
      ENSDARP00000017764.6, ENSDART00000018948.9
      Conserved Domains (1) summary
      cd10718
      Location:51 → 138
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394813.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      341176..346447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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