stk36 serine/threonine kinase 36 (fused homolog, Drosophila) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stk36provided by ZNC
Official Full Name: serine/threonine kinase 36 (fused homolog, Drosophila)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030912-6
See related: Ensembl:ENSDARG00000061095 AllianceGenome:ZFIN:ZDB-GENE-030912-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fu; zgc:152944; si:dkey-180i4.3
Summary: Predicted to enable ATP binding activity and protein kinase activity. Acts upstream of or within several processes, including axoneme assembly; determination of left/right symmetry; and smoothened signaling pathway. Predicted to be active in cytoplasm. Is expressed in neural tube. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (30392153..30411253)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (29792000..29811100)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zebrafish Fu is required both for Hh signalling and cilia biogenesis in Kupffer's vesicle [fused]
Title: Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase 36

Names: fused

NP_001071039.2

EC 2.7.11.1

XP_009299810.1

EC 2.7.11.1

XP_009299811.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077571.2 → NP_001071039.2 serine/threonine-protein kinase 36

See identical proteins and their annotated locations for NP_001071039.2

Status: PROVISIONAL

Source sequence(s)

BC154435

UniProtKB/TrEMBL

A0A8M1NBU0, A8WFS2

Related

ENSDARP00000081199.4, ENSDART00000086765.5

Conserved Domains (2) summary

smart00220
Location:4 → 254

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14002
Location:2 → 254

STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

30392153..30411253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301535.2 → XP_009299810.1 serine/threonine-protein kinase 36 isoform X1

UniProtKB/TrEMBL

A0A8M3B9P5

Conserved Domains (2) summary

smart00220
Location:4 → 254

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14002
Location:2 → 254

STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
XM_009301536.2 → XP_009299811.1 serine/threonine-protein kinase 36 isoform X2

UniProtKB/TrEMBL

A0A8M3ASI9

Conserved Domains (2) summary

smart00220
Location:4 → 254

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14002
Location:2 → 254

STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36