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    hnrnpaba heterogeneous nuclear ribonucleoprotein A/Ba [ Danio rerio (zebrafish) ]

    Gene ID: 321466, updated on 25-Apr-2024

    Summary

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    Official Symbol
    hnrnpabaprovided by ZNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A/Baprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-185
    See related
    Ensembl:ENSDARG00000007960 AllianceGenome:ZFIN:ZDB-GENE-030131-185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hnrpab; hnrnpab; zeh1271; sqd-likeA; hm:zeh1271; wu:fa18g02; wu:fb07b06; wu:fb16c05
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including EVL; digestive system; fin; nervous system; and periderm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See hnrnpaba in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (6962255..6966131)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (6655553..6659404)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene receptor for activated C kinase 1 Neighboring gene NME/NM23 family member 5 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3, like Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene RUN and FYVE domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The expression of CPEB proteins is sequentially regulated during zebrafish oogenesis and embryogenesis. O'Connell ML, et al. Mol Reprod Dev, 2014 Apr. PMID 24474627
    2. Impacts of triclosan exposure on zebrafish early-life stage: Toxicity and acclimation mechanisms. Falisse E, et al. Aquat Toxicol, 2017 Aug. PMID 28605648
    3. Analysis of the zebrafish proteome during embryonic development. Lucitt MB, et al. Mol Cell Proteomics, 2008 May. PMID 18212345, Free PMC Article
    4. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Vejnar CE, et al. Genome Res, 2019 Jul. PMID 31227602, Free PMC Article
    5. Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. Cuello S, et al. Analyst, 2012 Nov 21. PMID 23014190

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein A/B; heterogeneous nuclear ribonucleoprotein A/Ba

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212587.3 → NP_997752.2  heterogeneous nuclear ribonucleoprotein A/Ba

      See identical proteins and their annotated locations for NP_997752.2

      Status: VALIDATED

      Source sequence(s)
      BC066454
      UniProtKB/TrEMBL
      A0A8N7XJ29, F8W4E3, Q4QRD8, Q6NYU8
      Related
      ENSDARP00000124217.2, ENSDART00000148447.3
      Conserved Domains (3) summary
      cd12584
      Location:149 → 228
      RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
      cd12757
      Location:70 → 144
      RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
      pfam08143
      Location:1 → 69
      CBFNT; CBFNT (NUC161) domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      6962255..6966131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169577.2 → XP_005169634.1  heterogeneous nuclear ribonucleoprotein A/B isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHF1
      Conserved Domains (3) summary
      cd12584
      Location:149 → 228
      RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
      cd12757
      Location:70 → 144
      RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
      pfam08143
      Location:1 → 69
      CBFNT; CBFNT (NUC161) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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