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    ppp1r14ab protein phosphatase 1, regulatory (inhibitor) subunit 14Ab [ Danio rerio (zebrafish) ]

    Gene ID: 393783, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ppp1r14abprovided by ZNC
    Official Full Name
    protein phosphatase 1, regulatory (inhibitor) subunit 14Abprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1783
    See related
    Ensembl:ENSDARG00000017710 AllianceGenome:ZFIN:ZDB-GENE-040426-1783
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73377
    Summary
    Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to act upstream of or within regulation of phosphorylation. Predicted to be located in cytoplasm. Is expressed in hindbrain neural plate; nervous system; neural tube; presumptive rhombomere 4; and ventral mesoderm. Orthologous to human PPP1R14A (protein phosphatase 1 regulatory inhibitor subunit 14A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ppp1r14ab in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20204625..20233010, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20268896..20297278, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 13b Neighboring gene exocyst complex component 3-like 2b Neighboring gene serine peptidase inhibitor, Kunitz type, 2 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger. Amo R, et al. Neuron, 2014 Dec 3. PMID 25467985
    2. TALE factors poise promoters for activation by Hox proteins. Choe SK, et al. Dev Cell, 2014 Jan 27. PMID 24480644, Free PMC Article
    3. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article
    4. The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. Lang I, et al. Int J Mol Sci, 2020 Aug 9. PMID 32784920, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC73377

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1, regulatory (inhibitor) subunit 14Ab
    Names
    ppp1r14al

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200810.1 → NP_957104.1  protein phosphatase 1, regulatory (inhibitor) subunit 14Ab

      See identical proteins and their annotated locations for NP_957104.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059686
      UniProtKB/TrEMBL
      Q6PBJ4
      Related
      ENSDARP00000112264.2, ENSDART00000123910.3
      Conserved Domains (1) summary
      pfam05361
      Location:1 → 139
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      20204625..20233010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481361.1 → XP_021337036.1  protein phosphatase 1, regulatory (inhibitor) subunit 14Ab isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLB3
      Conserved Domains (1) summary
      pfam05361
      Location:4 → 77
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394946.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      78088..116833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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