aurka aurora kinase A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aurkaprovided by ZNC
Official Full Name: aurora kinase Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-161
See related: Ensembl:ENSDARG00000012485 AllianceGenome:ZFIN:ZDB-GENE-040801-161
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb37c10; fc02c02; wu:fb37c10; wu:fc02c02; zgc:100912
Summary: Predicted to enable histone serine kinase activity. Acts upstream of or within mitotic cell cycle. Predicted to be located in microtubule. Predicted to be part of chromosome passenger complex. Predicted to be active in spindle microtubule; spindle midzone; and spindle pole centrosome. Is expressed in several structures, including caudal fin; immature eye; nervous system; somite; and spinal cord neural tube. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (60125055..60139655)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (60130132..60144746)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted inhibition of Plk1 in zebrafish embryos illustrates how centrosomal Plk1 underlies mitotic spindle assembly. Inhibition of kinetochore-associated pools of AurA blocks phosphorylation of microtubule-kinetochore components
Title: Subcellular drug targeting illuminates local kinase action.
Zebrafish Aurora-A is critically required for embryonic proliferation during development.
Title: Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death.

Submit: New GeneRIF Correction

General gene information

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Markers

fc01g01.x1 (e-PCR)
- UniSTS:203661

fb37c10.x1 (e-PCR)
- UniSTS:203155

fc02c02.x1 (e-PCR)
- UniSTS:203671

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within centrosome cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic centrosome separation	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole centrosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aurora kinase A

Names: serine/threonine-protein kinase 6

NP_001003640.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003640.2 → NP_001003640.1 aurora kinase A

See identical proteins and their annotated locations for NP_001003640.1

Status: PROVISIONAL

Source sequence(s)

BC078304

UniProtKB/TrEMBL

Q6DBZ4

Related

ENSDARP00000021253.3, ENSDART00000008224.5

Conserved Domains (2) summary

smart00220
Location:138 → 388

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14116
Location:132 → 389

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase