sap30l sap30-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sap30lprovided by ZNC
Official Full Name: sap30-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5287
See related: Ensembl:ENSDARG00000030213 AllianceGenome:ZFIN:ZDB-GENE-030131-5287
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77367; wu:fa26a11; wu:fc10g12; wu:fe36f07
Summary: Predicted to enable several functions, including non-sequence-specific DNA binding activity, bending; phosphatidylinositol phosphate binding activity; and zinc ion binding activity. Acts upstream of or within heart looping. Predicted to be located in nucleolus. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including anterior neural rod; pectoral fin bud; pericardial region; pleuroperitoneal region; and trunk. Orthologous to several human genes including SAP30L (SAP30 like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (45875789..45878872, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (45837442..45840525, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SAP30L regulates several transcriptional pathways in zebrafish embryos and is involved in the development of cardiac and hematopoietic systems.
Title: SAP30L (Sin3A-associated protein 30-like) is involved in regulation of cardiac development and hematopoiesis in zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Markers

AA605988 (e-PCR)
- UniSTS:206873

G46235 (e-PCR)
- UniSTS:107037

fe36f07.x1 (e-PCR)
- UniSTS:196393

fc10g12.x1 (e-PCR)
- UniSTS:192472

fc10g12.x1 (e-PCR)
- UniSTS:192473

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-sequence-specific DNA binding, bending	ISS Inferred from Sequence or Structural Similarity more info
enables nucleosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-5-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone deacetylase complex subunit SAP30L

Names: Sin3A associated protein p30-like; sin3 corepressor complex subunit SAP30L; sin3-associated protein p30-like; sin3A-associated protein p30-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214703.1 → NP_999868.1 histone deacetylase complex subunit SAP30L

See identical proteins and their annotated locations for NP_999868.1

Status: PROVISIONAL

Source sequence(s)

BC066447

UniProtKB/Swiss-Prot

Q6NYV5

Related

ENSDARP00000028875.7, ENSDART00000029763.8

Conserved Domains (2) summary

pfam13866
Location:20 → 90

zf-SAP30; SAP30 zinc-finger

pfam13867
Location:110 → 158

SAP30_Sin3_bdg; Sin3 binding region of histone deacetylase complex subunit SAP30