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    gabbr1a gamma-aminobutyric acid (GABA) B receptor, 1a [ Danio rerio (zebrafish) ]

    Gene ID: 373873, updated on 27-Mar-2024

    Summary

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    Official Symbol
    gabbr1aprovided by ZNC
    Official Full Name
    gamma-aminobutyric acid (GABA) B receptor, 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030904-5
    See related
    Ensembl:ENSDARG00000018967 AllianceGenome:ZFIN:ZDB-GENE-030904-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gabbr1
    Summary
    Predicted to enable G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Is expressed in female organism; male organism; and nervous system. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See gabbr1a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34716109..34845471, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34858513..34987677, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene lymphotoxin alpha (TNF superfamily, member 1) Neighboring gene tumor necrosis factor b (TNF superfamily, member 2) Neighboring gene SH3-binding domain protein 5-like, a Neighboring gene alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning. Baker MR, et al. Sci Rep, 2021 Jun 8. PMID 34103598, Free PMC Article
    2. Maintenance of Melanocyte Stem Cell Quiescence by GABA-A Signaling in Larval Zebrafish. Allen JR, et al. Genetics, 2019 Oct. PMID 31444245, Free PMC Article
    3. Immunohistochemical localization of GABA, GAD65, and the receptor subunits GABAAalpha1 and GABAB1 in the zebrafish cerebellum. Delgado L, et al. Cerebellum, 2008. PMID 18633686
    4. Behavioral plasticity and gene regulation in the brain during an intermittent ethanol exposure in adult zebrafish population. Paiva IM, et al. Pharmacol Biochem Behav, 2020 May. PMID 32194086
    5. Inhibition of Lrrk2 reduces ethanol preference in a model of acute exposure in zebrafish. Paiva IM, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2020 Jun 8. PMID 32032698

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled GABA receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid type B receptor subunit 1
    Names
    gaba1
    gamma-aminobutyric acid (GABA) B receptor, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      34716109..34845471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689405.8 → XP_694497.5  gamma-aminobutyric acid type B receptor subunit 1

      UniProtKB/TrEMBL
      A0A8N7UVF8
      Related
      ENSDARP00000004577.7, ENSDART00000009892.8
      Conserved Domains (5) summary
      cd06366
      Location:168 → 561
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      smart00032
      Location:98 → 155
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      pfam00003
      Location:601 → 855
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:184 → 541
      ANF_receptor; Receptor family ligand binding region
      pfam10211
      Location:883 → 925
      Ax_dynein_light; Axonemal dynein light chain
    Nucleotide Protein Strain
    Heading Accession and Version

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