NEU3 neuraminidase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NEU3provided by HGNC
Official Full Name: neuraminidase 3provided by HGNC
Primary source: HGNC:HGNC:7760
See related: Ensembl:ENSG00000162139 MIM:604617; AllianceGenome:HGNC:7760
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIAL3
Summary: This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 5.8), prostate (RPKM 5.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (74980515..75020676)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (74910079..74957510)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (74699689..74721952)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3.
Title: EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3.
The extracellular sialidase NEU3 primes neutrophils.
Title: The extracellular sialidase NEU3 primes neutrophils.
Sialidase NEU3 and its pathological significance.
Title: Sialidase NEU3 and its pathological significance.
Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis.
Title: Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis.
TGF-beta1 increases sialidase 3 expression in human lung epithelial cells by decreasing its degradation and upregulating its translation.
Title: TGF-β1 increases sialidase 3 expression in human lung epithelial cells by decreasing its degradation and upregulating its translation.
Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines.
Title: Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines.
Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.
Title: Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.
overexpression of NEU3 in glioblastoma U87MG cells activates the PI3K/Akt signaling pathway resulting in an increased radioresistance capacity and in an improved efficiency of double strand DNA-repair mechanisms after irradiation
Title: Overexpression of sialidase NEU3 increases the cellular radioresistance potential of U87MG glioblastoma cells.
this finding strongly supports the idea that Neu3 may contain a cytosolic-exposed domain.
Title: Human Sialidase Neu3 is S-Acylated and Behaves Like an Integral Membrane Protein.
This first demonstration of sialidase involvement in invasive potential of gliolastoma cells may point to NEU3 as an attractive treatment target of human gliomas
Title: Sialidase NEU3 defines invasive potential of human glioblastoma cells by regulating calpain-mediated proteolysis of focal adhesion proteins.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Removal of sialic acids from HIV-1 gp120 with neuraminidase (NA) enhances mannose-binding lectin (MBL) binding	PubMed
	env	The desialylation of HIV-1 gp120 with neuraminidase greatly augments the initial virus-cell interaction, leading to remarkably enhanced viral replication and cytopathogenicity	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-107164 (e-PCR)
- UniSTS:170275

NoName (e-PCR)
- UniSTS:482424

G63715 (e-PCR)
- UniSTS:140676

D11S3116 (e-PCR)
- UniSTS:152209

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables alpha-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
enables exo-alpha-(2->3)-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
enables exo-alpha-(2->3)-sialidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables exo-alpha-(2->6)-sialidase activity	IEA Inferred from Electronic Annotation more info
enables exo-alpha-(2->8)-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
enables exo-alpha-(2->8)-sialidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables exo-alpha-sialidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables exo-alpha-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
enables exo-alpha-sialidase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ganglioside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ganglioside catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycosphingolipid catabolic process	TAS Traceable Author Statement more info
involved_in negative regulation of clathrin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in oligosaccharide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in caveola	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sialidase-3

Names: N-acetyl-alpha-neuraminidase 3; ganglioside sialidase; ganglioside sialidasedis; membrane sialidase; sialidase 3 (membrane sialidase)

NP_001354789.1

EC 3.2.1.18

NP_001354790.1

EC 3.2.1.18

NP_001354791.1

EC 3.2.1.18

NP_001354792.1

EC 3.2.1.18

NP_001354793.1

EC 3.2.1.18

NP_001354794.1

EC 3.2.1.18

NP_001354795.1

EC 3.2.1.18

NP_001354796.1

EC 3.2.1.18

NP_006647.3

EC 3.2.1.18

XP_047282254.1

EC 3.2.1.18

XP_047282255.1

EC 3.2.1.18

XP_047282256.1

EC 3.2.1.18

XP_047282257.1

EC 3.2.1.18

XP_047282258.1

EC 3.2.1.18

XP_047282259.1

EC 3.2.1.18

XP_047282260.1

EC 3.2.1.18

XP_054223493.1

EC 3.2.1.18

XP_054223494.1

EC 3.2.1.18

XP_054223495.1

EC 3.2.1.18

XP_054223496.1

EC 3.2.1.18

XP_054223497.1

EC 3.2.1.18

XP_054223498.1

EC 3.2.1.18

XP_054223499.1

EC 3.2.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001367860.1 → NP_001354789.1 sialidase-3 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).

Source sequence(s)

AP001992, BC136397

Consensus CDS

CCDS44682.1

UniProtKB/Swiss-Prot

A8K327, Q9NQE1, Q9UQ49

Related

ENSP00000432097.1, ENST00000531509.5
NM_001367861.1 → NP_001354790.1 sialidase-3 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variant 4, encodes isoform b.

Source sequence(s)

AP001992

Consensus CDS

CCDS91538.1

UniProtKB/TrEMBL

E9PNK1

Conserved Domains (1) summary

cd15482
Location:44 → 93

Sialidase_non-viral; Non-viral sialidases
NM_001367862.1 → NP_001354791.1 sialidase-3 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variant 3, encodes isoform b.

Source sequence(s)

AP001992, DB099096

Consensus CDS

CCDS91538.1

UniProtKB/TrEMBL

E9PNK1

Related

ENSP00000434754.1, ENST00000534628.1

Conserved Domains (1) summary

cd15482
Location:44 → 93

Sialidase_non-viral; Non-viral sialidases
NM_001367863.1 → NP_001354792.1 sialidase-3 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variant 6, encodes isoform c.

Source sequence(s)

AP001992

Consensus CDS

CCDS91539.1

UniProtKB/TrEMBL

E9PMZ3

Related

ENSP00000434474.1, ENST00000529024.1
NM_001367864.1 → NP_001354793.1 sialidase-3 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variant 5, encodes isoform c.

Source sequence(s)

AK303540, AP001992

Consensus CDS

CCDS91539.1

UniProtKB/TrEMBL

E9PMZ3

Related

ENSP00000434907.1, ENST00000532963.1
NM_001367865.1 → NP_001354794.1 sialidase-3 isoform d

Status: REVIEWED

Source sequence(s)

AP001992
NM_001367866.1 → NP_001354795.1 sialidase-3 isoform e

Status: REVIEWED

Source sequence(s)

AP001992, BP352846

Consensus CDS

CCDS91537.1

UniProtKB/TrEMBL

E9PR25

Related

ENSP00000436118.1, ENST00000531619.1

Conserved Domains (1) summary

cd15482
Location:44 → 126

Sialidase_non-viral; Non-viral sialidases
NM_001367867.2 → NP_001354796.1 sialidase-3 isoform f

Status: REVIEWED

Source sequence(s)

AP001992, BX108543

Consensus CDS

CCDS91536.1

UniProtKB/TrEMBL

E9PI40

Related

ENSP00000436540.1, ENST00000526068.1
NM_006656.6 → NP_006647.3 sialidase-3 isoform a

See identical proteins and their annotated locations for NP_006647.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AP001992, CN429425, DB240271

Consensus CDS

CCDS44682.1

UniProtKB/Swiss-Prot

A8K327, Q9NQE1, Q9UQ49

Related

ENSP00000294064.4, ENST00000294064.9

Conserved Domains (2) summary

cd15482
Location:44 → 436

Sialidase_non-viral; Non-viral sialidases

pfam13088
Location:70 → 417

BNR_2; BNR repeat-like domain