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    Kctd16 potassium channel tetramerization domain containing 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291618, updated on 2-May-2024

    Summary

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    Official Symbol
    Kctd16provided by RGD
    Official Full Name
    potassium channel tetramerization domain containing 16provided by RGD
    Primary source
    RGD:1559856
    See related
    Ensembl:ENSRNOG00000069221 AllianceGenome:RGD:1559856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559856
    Summary
    Predicted to act upstream of or within regulation of G protein-coupled receptor signaling pathway. Predicted to be located in postsynaptic membrane and presynaptic membrane. Predicted to be part of receptor complex. Orthologous to human KCTD16 (potassium channel tetramerization domain containing 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 425.7), Brain (RPKM 143.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kctd16 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (32417306..32711928)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (32166236..32473067)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (33443362..33730642)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene Yip1 domain family, member 5 Neighboring gene ubiquitin-conjugating enzyme E2C, pseudogene 3 Neighboring gene transfer RNA proline (anticodon AGG) 42 Neighboring gene igE-binding protein-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Schwenk J, et al. Nature, 2010 May 13. PMID 20400944

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD16
    Names
    potassium channel tetramerisation domain containing 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172155.1 → NP_001165626.1  BTB/POZ domain-containing protein KCTD16

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6A6D0
      Conserved Domains (2) summary
      cd18398
      Location:23 → 125
      BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
      cd22219
      Location:160 → 280
      H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      32417306..32711928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600896.3 → XP_017456385.1  BTB/POZ domain-containing protein KCTD16 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6D0
      Conserved Domains (2) summary
      cd18398
      Location:23 → 125
      BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
      cd22219
      Location:160 → 280
      H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

    2. XM_017600895.3 → XP_017456384.1  BTB/POZ domain-containing protein KCTD16 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6D0
      Related
      ENSRNOP00000087696.1
      Conserved Domains (2) summary
      cd18398
      Location:23 → 125
      BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
      cd22219
      Location:160 → 280
      H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

    3. XM_017600897.3 → XP_017456386.1  BTB/POZ domain-containing protein KCTD16 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6D0
      Conserved Domains (2) summary
      cd18398
      Location:23 → 125
      BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
      cd22219
      Location:160 → 280
      H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

    4. XM_039096706.2 → XP_038952634.1  BTB/POZ domain-containing protein KCTD16 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6D0
      Conserved Domains (2) summary
      cd18398
      Location:23 → 125
      BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
      cd22219
      Location:160 → 280
      H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16
    Nucleotide Protein Strain
    Heading Accession and Version

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