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    Rgs22 regulator of G-protein signaling 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500853, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rgs22provided by RGD
    Official Full Name
    regulator of G-protein signaling 22provided by RGD
    Primary source
    RGD:1565493
    See related
    Ensembl:ENSRNOG00000025551 AllianceGenome:RGD:1565493
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565493
    Summary
    Predicted to enable G-protein alpha-subunit binding activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in actin cytoskeleton; cytosol; and fibrillar center. Orthologous to human RGS22 (regulator of G protein signaling 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 381.1), Lung (RPKM 74.0) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rgs22 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (69073681..69194041, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (67188531..67308805, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (74783009..74902049, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene pre-mRNA-splicing factor CWC22 homolog Neighboring gene ribosomal protein S24, pseudogene 17 Neighboring gene uncharacterized LOC134479892 Neighboring gene F-box protein 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. Hu Y, et al. Biol Reprod, 2008 Dec. PMID 18703424
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      69073681..69194041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264609.1 → XP_063120679.1  regulator of G-protein signaling 22 isoform X5

    2. XM_039080154.2 → XP_038936082.1  regulator of G-protein signaling 22 isoform X3

      Conserved Domains (3) summary
      cd08725
      Location:1005 → 1127
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:832 → 961
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cl02565
      Location:663 → 765
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. XM_039080158.2 → XP_038936086.1  regulator of G-protein signaling 22 isoform X6

      Conserved Domains (3) summary
      cd08726
      Location:845 → 974
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:663 → 778
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:997 → 1086
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. XM_039080157.2 → XP_038936085.1  regulator of G-protein signaling 22 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AM59
      Related
      ENSRNOP00000095785.1
      Conserved Domains (3) summary
      cd08725
      Location:1018 → 1140
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:845 → 974
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:663 → 778
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

    5. XM_006241548.5 → XP_006241610.1  regulator of G-protein signaling 22 isoform X1

      UniProtKB/TrEMBL
      F1LX91
      Related
      ENSRNOP00000034120.4
      Conserved Domains (3) summary
      cd08725
      Location:1018 → 1140
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:845 → 974
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:663 → 778
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

    6. XM_063264607.1 → XP_063120677.1  regulator of G-protein signaling 22 isoform X2

    7. XM_039080159.2 → XP_038936087.1  regulator of G-protein signaling 22 isoform X7

      Conserved Domains (3) summary
      cd08725
      Location:569 → 691
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:396 → 525
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:214 → 329
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

    RNA

    1. XR_010053752.1 RNA Sequence

    2. XR_010053751.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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