Fuca1 alpha-L-fucosidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fuca1provided by RGD
Official Full Name: alpha-L-fucosidase 1provided by RGD
Primary source: RGD:2636
See related: Ensembl:ENSRNOG00000009325 AllianceGenome:RGD:2636
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fuca
Summary: Enables carbohydrate binding activity and fucosidase activity. Predicted to be involved in fucose metabolic process and glycoside catabolic process. Located in lysosome. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to human FUCA1 (alpha-L-fucosidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 723.6), Testes (RPKM 474.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (153436262..153453512)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (148152718..148169972)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (154269296..154286545)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH94576 (e-PCR)
- UniSTS:119824

AI579525 (e-PCR)
- UniSTS:249409

AU026958 (e-PCR)
- UniSTS:113768

D5Mco22 (e-PCR)
- UniSTS:239355

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-L-fucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-L-fucosidase activity	IEA Inferred from Electronic Annotation more info
enables alpha-L-fucosidase activity	ISO Inferred from Sequence Orthology more info
enables alpha-L-fucosidase activity	NAS Non-traceable Author Statement more info	PubMed
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables fucosidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in fucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fucose metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in glycoside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycoside catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycoside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycoside catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tissue alpha-L-fucosidase

Names: Fucosidase, alpha-L-1, tissue; alpha-L-fucosidase I; alpha-L-fucoside fucohydrolase 1; fucosidase, alpha-L- 1, tissue

NP_036694.2

EC 3.2.1.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012562.2 → NP_036694.2 tissue alpha-L-fucosidase precursor

See identical proteins and their annotated locations for NP_036694.2

Status: PROVISIONAL

Source sequence(s)

BC081844

UniProtKB/Swiss-Prot

P17164, Q642C6

UniProtKB/TrEMBL

A0A0G2JSJ8, A6IT76

Related

ENSRNOP00000012455.3, ENSRNOT00000012455.6

Conserved Domains (3) summary

smart00812
Location:27 → 409

Alpha_L_fucos; Alpha-L-fucosidase

COG3669
Location:59 → 402

AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]

pfam16757
Location:382 → 459

Fucosidase_C; Alpha-L-fucosidase C-terminal domain