Defb22 defensin beta 22 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Defb22provided by RGD
Official Full Name: defensin beta 22provided by RGD
Primary source: RGD:708352
See related: Ensembl:ENSRNOG00000007525 AllianceGenome:RGD:708352
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 2D6glycoprotein
Summary: Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to Gram-negative bacterium. Predicted to be located in cell surface and glycocalyx. Orthologous to human DEFB126 (defensin beta 126). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (161417380..161421659, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (140957093..140961373, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (147961818..147966097, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Demonstrated the antimicrobial activity of recombinant beta-defensin 22 against E coli and Candida albicans. It has lectin-like ability, binding to heparin beads. This heparin-binding activity implies potential roles in fertilisation capabilities of sperm.
Title: Rat recombinant β-defensin 22 is a heparin-binding protein with antimicrobial activity.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in sperm glycocalyx	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-defensin 126

Names: 2D6 glycoprotein; E-3 epididymal fluid protein; beta-defensin 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.