Lrguk leucine-rich repeats and guanylate kinase domain containing [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrgukprovided by RGD
Official Full Name: leucine-rich repeats and guanylate kinase domain containingprovided by RGD
Primary source: RGD:1308226
See related: Ensembl:ENSRNOG00000008775 AllianceGenome:RGD:1308226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308226
Summary: Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. Orthologous to human LRGUK (leucine rich repeats and guanylate kinase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 21.3), Lung (RPKM 10.5) and 2 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q22

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (63614431..63737463)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (62647222..62770268)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (61419987..61544748)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in GDP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in manchette	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: leucine-rich repeat and guanylate kinase domain-containing protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106589.2 → NP_001100059.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 2

See identical proteins and their annotated locations for NP_001100059.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IEK9, D4A3R3

Conserved Domains (6) summary

cd00071
Location:415 → 591

GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...

cd00116
Location:149 → 338

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:129 → 149

LRR_RI; leucine-rich repeat [structural motif]

pfam00625
Location:416 → 598

Guanylate_kin; Guanylate kinase

pfam12799
Location:259 → 299

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:281 → 338

LRR_8; Leucine rich repeat
NM_001401524.2 → NP_001388453.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6GHE9

Related

ENSRNOP00000088777.1, ENSRNOT00000108064.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

63614431..63737463

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017592528.3 → XP_017448017.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X1
XM_017592530.3 → XP_017448019.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X4

UniProtKB/TrEMBL

D4A3R3

Related

ENSRNOP00000069992.1
XM_063285744.1 → XP_063141814.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X5

UniProtKB/TrEMBL

A0A0G2JWS1, D4A3R3
XM_006236253.5 → XP_006236315.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X3

UniProtKB/TrEMBL

D4A3R3

Related

ENSRNOP00000011692.7

Conserved Domains (6) summary

cd00071
Location:416 → 592

GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...

cd00116
Location:149 → 339

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:129 → 149

LRR_RI; leucine-rich repeat [structural motif]

pfam00625
Location:417 → 599

Guanylate_kin; Guanylate kinase

pfam12799
Location:260 → 300

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:282 → 339

LRR_8; Leucine rich repeat
XM_039107286.2 → XP_038963214.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X7

UniProtKB/TrEMBL

D4A3R3

Conserved Domains (4) summary

cd00071
Location:416 → 592

GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...

sd00033
Location:129 → 149

LRR_RI; leucine-rich repeat [structural motif]

NF033189
Location:130 → 258

internalin_A; class 1 internalin InlA

cd21340
Location:200 → 369

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_039107288.2 → XP_038963216.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X12

Conserved Domains (4) summary

sd00033
Location:129 → 149

LRR_RI; leucine-rich repeat [structural motif]

NF033189
Location:130 → 258

internalin_A; class 1 internalin InlA

cd21340
Location:200 → 369

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl17190
Location:416 → 475

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039107289.2 → XP_038963217.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X13

Conserved Domains (4) summary

sd00033
Location:129 → 149

LRR_RI; leucine-rich repeat [structural motif]

NF033189
Location:130 → 258

internalin_A; class 1 internalin InlA

cd21340
Location:200 → 369

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl17190
Location:416 → 448

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063285745.1 → XP_063141815.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X8

UniProtKB/TrEMBL

D4A3R3
XM_017592531.3 → XP_017448020.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X10
XM_063285746.1 → XP_063141816.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X11
XM_063285743.1 → XP_063141813.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X2
XM_039107285.2 → XP_038963213.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X6

Conserved Domains (2) summary

PHA03247
Location:207 → 705

PHA03247; large tegument protein UL36; Provisional

cl17190
Location:1 → 126

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039107287.2 → XP_038963215.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform X9

Conserved Domains (2) summary

PHA03247
Location:169 → 667

PHA03247; large tegument protein UL36; Provisional

cl17190
Location:2 → 88

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...