Rpl30 ribosomal protein L30 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rpl30provided by RGD
Official Full Name: ribosomal protein L30provided by RGD
Primary source: RGD:621201
See related: AllianceGenome:RGD:621201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables selenocysteine insertion sequence binding activity. Involved in liver regeneration and positive regulation of selenocysteine incorporation. Located in ribosome. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in herpes simplex. Orthologous to human RPL30 (ribosomal protein L30). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 4041.0), Thymus (RPKM 3551.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (67533420..67536555, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (65648266..65651401, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (73213538..73216431, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

L30 and SBP2 bind to overlapping but non-identical sites on the SECIS.
Title: Identification of nucleotides and amino acids that mediate the interaction between ribosomal protein L30 and the SECIS element.
L30 binds selenocysteine insertion sequence elements in vitro and in vivo, stimulates UGA recoding in transfected cells
Title: Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC152246P1 (e-PCR)
- UniSTS:271203

MARC_1295-1296:991931143:1 (e-PCR)
- UniSTS:230857

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables selenocysteine insertion sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of selenocysteine incorporation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: large ribosomal subunit protein eL30

Names: 60S ribosomal protein L30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022699.4 → NP_073190.1 large ribosomal subunit protein eL30

See identical proteins and their annotated locations for NP_073190.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P62890

UniProtKB/TrEMBL

A6HEB4, F1M3Q4

Conserved Domains (1) summary

PTZ00106
Location:2 → 107

PTZ00106; 60S ribosomal protein L30; Provisional