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    Rundc3a RUN domain containing 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303569, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rundc3aprovided by RGD
    Official Full Name
    RUN domain containing 3Aprovided by RGD
    Primary source
    RGD:735057
    See related
    Ensembl:ENSRNOG00000020970 AllianceGenome:RGD:735057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GCRP; Rap2ip
    Summary
    Involved in positive regulation of cGMP-mediated signaling. Located in cytosol and plasma membrane. Orthologous to human RUNDC3A (RUN domain containing 3A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 324.7), Adrenal (RPKM 23.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rundc3a in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87852746..87861903)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87352624..87361767)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90342033..90351172)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 1 (Diego blood group) Neighboring gene partner of NOB1 homolog (S. cerevisiae), pseudogene 1 Neighboring gene solute carrier family 25, member 39 Neighboring gene granulin precursor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A. Chen ZJ, et al. Biochem Biophys Res Commun, 2000 Nov 11. PMID 11071862
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RUN domain-containing protein 3A
    Names
    Rap2 interacting protein
    guanylate-cyclase regulatory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198758.2 → NP_942053.2  RUN domain-containing protein 3A

      Status: VALIDATED

      Source sequence(s)
      BC127472, CB797318, DY319760
      UniProtKB/TrEMBL
      A6HJI9, F1LRZ9
      Related
      ENSRNOP00000028487.2, ENSRNOT00000028487.4
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 186
      RUN; RUN domain
      pfam06785
      Location:238 → 318
      UPF0242; Uncharacterized protein family (UPF0242)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      87852746..87861903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247339.5 → XP_006247401.1  RUN domain-containing protein 3A isoform X11

      UniProtKB/TrEMBL
      A6HJI9
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 186
      RUN; RUN domain
      pfam06785
      Location:238 → 318
      UPF0242; Uncharacterized protein family (UPF0242)

    2. XM_008768058.4 → XP_008766280.1  RUN domain-containing protein 3A isoform X4

      UniProtKB/TrEMBL
      A6HJI9
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 181
      RUN; RUN domain
      pfam06785
      Location:233 → 313
      UPF0242; Uncharacterized protein family (UPF0242)

    3. XM_017597324.3 → XP_017452813.1  RUN domain-containing protein 3A isoform X6

      UniProtKB/TrEMBL
      A0A0G2JW67, A6HJI9
      Related
      ENSRNOP00000069763.2
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 186
      RUN; RUN domain
      pfam06785
      Location:238 → 318
      UPF0242; Uncharacterized protein family (UPF0242)

    4. XM_017597325.3 → XP_017452814.1  RUN domain-containing protein 3A isoform X10

      UniProtKB/TrEMBL
      A6HJI9
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 186
      RUN; RUN domain
      pfam06785
      Location:238 → 318
      UPF0242; Uncharacterized protein family (UPF0242)

    5. XM_006247335.5 → XP_006247397.1  RUN domain-containing protein 3A isoform X2

      See identical proteins and their annotated locations for XP_006247397.1

      UniProtKB/TrEMBL
      A6HJI8, A6HJI9
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 186
      RUN; RUN domain
      pfam06785
      Location:238 → 318
      UPF0242; Uncharacterized protein family (UPF0242)

    6. XM_063269161.1 → XP_063125231.1  RUN domain-containing protein 3A isoform X12

    7. XM_039086113.2 → XP_038942041.1  RUN domain-containing protein 3A isoform X7

      UniProtKB/TrEMBL
      A6HJI9
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 182
      RUN; RUN domain
      pfam06785
      Location:234 → 314
      UPF0242; Uncharacterized protein family (UPF0242)

    8. XM_017597323.3 → XP_017452812.1  RUN domain-containing protein 3A isoform X1

      UniProtKB/TrEMBL
      A1L117
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 181
      RUN; RUN domain
      pfam06785
      Location:233 → 313
      UPF0242; Uncharacterized protein family (UPF0242)

    9. XM_006247340.5 → XP_006247402.1  RUN domain-containing protein 3A isoform X8

      UniProtKB/TrEMBL
      A6HJI9
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 181
      RUN; RUN domain
      pfam06785
      Location:233 → 313
      UPF0242; Uncharacterized protein family (UPF0242)

    10. XM_063269160.1 → XP_063125230.1  RUN domain-containing protein 3A isoform X9

    11. XM_063269162.1 → XP_063125232.1  RUN domain-containing protein 3A isoform X13

    12. XM_063269158.1 → XP_063125228.1  RUN domain-containing protein 3A isoform X3

    13. XM_063269159.1 → XP_063125229.1  RUN domain-containing protein 3A isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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