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    Rgmb repulsive guidance molecule BMP co-receptor b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681433, updated on 5-Mar-2024

    Summary

    Symbol
    Rgmbprovided by RGD
    Full Name
    repulsive guidance molecule BMP co-receptor bprovided by RGD
    Primary source
    RGD:1595392
    See related
    Ensembl:ENSRNOG00000064721 AllianceGenome:RGD:1595392
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable coreceptor activity and identical protein binding activity. Predicted to be involved in BMP signaling pathway and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within cell adhesion. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment. Predicted to be anchored component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human RGMB (repulsive guidance molecule BMP co-receptor b). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 78.4), Brain (RPKM 74.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rgmb in Genome Data Viewer
    Location:
    1q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (65439748..65465149, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (56766598..56792396, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (57794046..57819941, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485094 Neighboring gene chromodomain helicase DNA binding protein 1 like 2 Neighboring gene chromodomain helicase DNA binding protein 1 Neighboring gene ubiquitin-conjugating enzyme E2 L3-like Neighboring gene mitochondrial fission regulator 2, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    repulsive guidance molecule B
    Names
    RGM domain family, member B
    repulsive guidance molecule family member B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      65439748..65465149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227982.5XP_006228044.1  repulsive guidance molecule B

      See identical proteins and their annotated locations for XP_006228044.1

      UniProtKB/TrEMBL
      A0A8I5ZSB8, A6KB58, M0RB24
      Related
      ENSRNOP00000066746.2
      Conserved Domains (2) summary
      pfam06534
      Location:270449
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:98265
      RGM_N; Repulsive guidance molecule (RGM) N-terminus