trim25 tripartite motif containing 25 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trim25provided by ZNC
Official Full Name: tripartite motif containing 25provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-797
See related: Ensembl:ENSDARG00000104396 AllianceGenome:ZFIN:ZDB-GENE-040426-797
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55773
Summary: Predicted to enable zinc ion binding activity. Acts upstream of or within regulation of RIG-I signaling pathway. Is expressed in several structures, including gill; integument; male organism; muscle; and pleuroperitoneal region. Orthologous to human TRIM25 (tripartite motif containing 25). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (18388116..18400620, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (21916798..21929308, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity.
Title: Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity.
Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination.
Title: Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of RIG-I signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin/ISG15 ligase TRIM25

NP_956469.1

EC 6.3.2.19

XP_017211938.1

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200175.1 → NP_956469.1 E3 ubiquitin/ISG15 ligase TRIM25

See identical proteins and their annotated locations for NP_956469.1

Status: PROVISIONAL

Source sequence(s)

BC045450

UniProtKB/TrEMBL

Q7ZVQ7

Related

ENSDARP00000134454.1, ENSDART00000164891.2

Conserved Domains (4) summary

pfam00643
Location:152 → 184

zf-B_box; B-box zinc finger

cl02614
Location:482 → 650

SPRY; SPRY domain

cl17238
Location:16 → 56

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:199 → 307

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

18388116..18400620 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017356449.2 → XP_017211938.1 E3 ubiquitin/ISG15 ligase TRIM25 isoform X1

UniProtKB/TrEMBL

A0A2R8QTG3, A0A8M6Z112

Related

ENSDARP00000156782.1, ENSDART00000179797.1

Conserved Domains (4) summary

cd00162
Location:15 → 57

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00643
Location:152 → 184

zf-B_box; B-box zinc finger

cl02614
Location:473 → 641

SPRY; SPRY domain

cl23765
Location:199 → 307

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits