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    fes FES proto-oncogene, tyrosine kinase [ Danio rerio (zebrafish) ]

    Gene ID: 566739, updated on 11-Apr-2024

    Summary

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    Official Symbol
    fesprovided by ZNC
    Official Full Name
    FES proto-oncogene, tyrosine kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100812-10
    See related
    Ensembl:ENSDARG00000011449 AllianceGenome:ZFIN:ZDB-GENE-100812-10
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including innate immune response; regulation of mast cell degranulation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See fes in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (14211148..14266254)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (13965859..14020788)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene stereocilin-like Neighboring gene stereocilin-like Neighboring gene furin (paired basic amino acid cleaving enzyme) a Neighboring gene Rh family, C glycoprotein a Neighboring gene uncharacterized LOC108190637

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Nodal signaling range is regulated by proprotein convertase-mediated maturation. Tessadori F, et al. Dev Cell, 2015 Mar 9. PMID 25684355
    2. Irf8 regulates the progression of myeloproliferative neoplasm-like syndrome via Mertk signaling in zebrafish. Zhao F, et al. Leukemia, 2018 Jan. PMID 28626217
    3. Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology. Challa AK, et al. Zebrafish, 2013 Sep. PMID 23234507, Free PMC Article
    4. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
    5. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase Fes/Fps
    Names
    feline sarcoma oncogene
    NP_001186798.1
    XP_005166438.1
    XP_005166440.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199869.1 → NP_001186798.1  tyrosine-protein kinase Fes/Fps

      Status: VALIDATED

      Source sequence(s)
      CU467822, CU469517
      UniProtKB/TrEMBL
      A0A2R8Q7T0, A0A8M1NXI9
      Related
      ENSDARP00000147268.1, ENSDART00000180985.1
      Conserved Domains (4) summary
      cd07685
      Location:7 → 243
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:457 → 541
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:568 → 822
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:565 → 821
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      14211148..14266254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166381.4 → XP_005166438.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDT6
      Conserved Domains (4) summary
      cd07685
      Location:7 → 243
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:466 → 550
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      pfam07714
      Location:574 → 830
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:577 → 831
      PKc_like; Protein Kinases, catalytic domain

    2. XM_005166383.4 → XP_005166440.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      A0A8M2BDW8, F8W425
      Related
      ENSDARP00000124270.1, ENSDART00000149938.4
      Conserved Domains (4) summary
      cd07685
      Location:7 → 243
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:457 → 541
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:568 → 822
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:565 → 821
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein
    Heading Accession and Version

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