prdx5 peroxiredoxin 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prdx5provided by ZNC
Official Full Name: peroxiredoxin 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-159
See related: Ensembl:ENSDARG00000055064 AllianceGenome:ZFIN:ZDB-GENE-050522-159
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112318
Summary: Predicted to enable thioredoxin peroxidase activity. Acts upstream of or within fin regeneration. Predicted to be located in peroxisomal matrix. Predicted to be active in mitochondrion and peroxisome. Is expressed in several structures, including alar plate midbrain region; macrophage; optic vesicle; pronephric duct; and sensory system. Orthologous to human PRDX5 (peroxiredoxin 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (26657473..26664826)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (26620778..26628131)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The synergistic effects of PRDX5 and Nrf2 on lung cancer progression and drug resistance under oxidative stress in the zebrafish models.
Title: The synergistic effects of PRDX5 and Nrf2 on lung cancer progression and drug resistance under oxidative stress in the zebrafish models.

Submit: New GeneRIF Correction

General gene information

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Markers

fb08e11.x1 (e-PCR)
- UniSTS:202757

fb61e06.x1 (e-PCR)
- UniSTS:203383

fe05e09.x1 (e-PCR)
- UniSTS:195988

fb61e06 (e-PCR)
- UniSTS:187302

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin peroxidase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fin regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peroxiredoxin-5, mitochondrial

NP_001019577.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024406.1 → NP_001019577.1 peroxiredoxin-5, mitochondrial

See identical proteins and their annotated locations for NP_001019577.1

Status: PROVISIONAL

Source sequence(s)

BC095755

UniProtKB/TrEMBL

A0A8M1N6S8, Q502C8

Related

ENSDARP00000151292.1, ENSDART00000186550.1

Conserved Domains (1) summary

cd03013
Location:5 → 160

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...