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    mxa myxovirus (influenza) resistance A [ Danio rerio (zebrafish) ]

    Gene ID: 360142, updated on 27-Mar-2024

    Summary

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    Official Symbol
    mxaprovided by ZNC
    Official Full Name
    myxovirus (influenza) resistance Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030721-5
    See related
    Ensembl:ENSDARG00000021688 AllianceGenome:ZFIN:ZDB-GENE-030721-5
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Mx; fj23d12; wu:fj23d12; zgc:136725
    Summary
    Predicted to enable GTPase activity and microtubule binding activity. Acts upstream of or within response to arsenic-containing substance; response to bacterium; and response to virus. Predicted to be active in several cellular components, including cytoplasm; microtubule; and nucleus. Is expressed in several structures, including digestive system; gill; heart; immune system; and muscle. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1) and MX2 (MX dynamin like GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mxa in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (7562323..7570219, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (6878890..6886786, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene myosin, light polypeptide 3, skeletal muscle Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene myxovirus (influenza) resistance B Neighboring gene ephrin-B2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio. Altmann SM, et al. Dev Comp Immunol, 2004 Apr. PMID 14698216
    2. shRNAs targeting either the glycoprotein or polymerase genes inhibit Viral haemorrhagic septicaemia virus replication in zebrafish ZF4 cells. Clarke BD, et al. Antiviral Res, 2017 May. PMID 28237822
    3. Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses. Sullivan C, et al. J Vis Exp, 2017 Jan 20. PMID 28190053, Free PMC Article
    4. Influenza A virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment. Gabor KA, et al. Dis Model Mech, 2014 Nov. PMID 25190709, Free PMC Article
    5. Molecular and functional analysis of an interferon gene from the zebrafish, Danio rerio. Altmann SM, et al. J Virol, 2003 Feb. PMID 12525633, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning and analysis of an Mx gene and its corresponding promoter
      Title: Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136725

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to arsenic-containing substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced GTP-binding protein MxA
    Names
    IFN-inducible antiviral protein MxA
    interferon-inducible MxA protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182942.4 → NP_891987.2  interferon-induced GTP-binding protein MxA

      Status: VALIDATED

      Source sequence(s)
      CT998565
      UniProtKB/Swiss-Prot
      Q8JH68
      UniProtKB/TrEMBL
      A0A8M1PAS6, B8JKI3
      Related
      ENSDARP00000094364.3, ENSDART00000103588.5
      Conserved Domains (3) summary
      cd08771
      Location:35 → 307
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:228 → 510
      Dynamin_M; Dynamin central region
      pfam02212
      Location:547 → 632
      GED; Dynamin GTPase effector domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      7562323..7570219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JH68.1 GenPept UniProtKB/Swiss-Prot:Q8JH68

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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