nell2a neural EGFL like 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nell2aprovided by ZNC
Official Full Name: neural EGFL like 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7972
See related: AllianceGenome:ZFIN:ZDB-GENE-030131-7972
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nell2; wu:fj43h11; zgc:158375
Summary: Predicted to enable heparin binding activity and protein kinase C binding activity. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Orthologous to human NELL2 (neural EGFL like 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (581140..692366)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (558243..669469)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj43h11.x1 (e-PCR)
- UniSTS:188562

Z8380 (e-PCR)
- UniSTS:46007

G39504 (e-PCR)
- UniSTS:67542

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in fertilization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein kinase C-binding protein NELL2a

Names: NEL-like 2; NEL-like 2a; Protein kinase C-binding protein NELL2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080075.1 → NP_001073544.1 protein kinase C-binding protein NELL2a precursor

See identical proteins and their annotated locations for NP_001073544.1

Status: PROVISIONAL

Source sequence(s)

BC128854

UniProtKB/Swiss-Prot

A1A5Y0

Conserved Domains (5) summary

smart00179
Location:553 → 587

EGF_CA; Calcium-binding EGF-like domain

pfam07645
Location:600 → 631

EGF_CA; Calcium-binding EGF domain

pfam12947
Location:484 → 519

EGF_3; EGF domain

cl17735
Location:271 → 327

VWC; von Willebrand factor type C domain

cl22861
Location:40 → 211

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...