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    pkma pyruvate kinase M1/2a [ Danio rerio (zebrafish) ]

    Gene ID: 335817, updated on 30-Mar-2024

    Summary

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    Official Symbol
    pkmaprovided by ZNC
    Official Full Name
    pyruvate kinase M1/2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031201-4
    See related
    Ensembl:ENSDARG00000099730 AllianceGenome:ZFIN:ZDB-GENE-031201-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pkm2; pkm2a; cb1029; fj33f03; wu:fj33f03
    Summary
    Predicted to enable pyruvate kinase activity. Involved in sprouting angiogenesis. Predicted to be active in cytoplasm. Is expressed in several structures, including nervous system; neural tube; otic vesicle; pericardial region; and solid lens vesicle. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See pkma in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (910938..951570)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (1018606..1059200)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene si:dkey-205h23.1 Neighboring gene poly (ADP-ribose) polymerase family, member 6a Neighboring gene dihydrodiol dehydrogenase, tandem duplicate 2 Neighboring gene dihydrodiol dehydrogenase, tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Base editing-mediated perturbation of endogenous PKM1/2 splicing facilitates isoform-specific functional analysis in vitro and in vivo. Lin J, et al. Cell Prolif, 2021 Aug. PMID 34240779, Free PMC Article
    2. Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Stone OA, et al. Nat Commun, 2018 Oct 9. PMID 30301887, Free PMC Article
    3. Metabolic modulation regulates cardiac wall morphogenesis in zebrafish. Fukuda R, et al. Elife, 2019 Dec 23. PMID 31868165, Free PMC Article
    4. Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. Li Z, et al. PLoS One, 2015. PMID 26147004, Free PMC Article
    5. Notch signaling regulates the expression of glycolysis-related genes in a context-dependent manner during embryonic development. Kuwabara S, et al. Biochem Biophys Res Commun, 2018 Sep 5. PMID 29913146

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate kinase PKM
    Names
    pyruvate kinase, muscle, a
    NP_955365.1
    XP_009291639.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199333.1 → NP_955365.1  pyruvate kinase PKM

      See identical proteins and their annotated locations for NP_955365.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045421
      UniProtKB/TrEMBL
      B2GQD5, Q7ZVT2
      Related
      ENSDARP00000140346.1, ENSDART00000167229.3
      Conserved Domains (2) summary
      cd00288
      Location:43 → 531
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:44 → 528
      pyruv_kin; pyruvate kinase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      910938..951570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293364.2 → XP_009291639.1  pyruvate kinase PKM isoform X1

      UniProtKB/TrEMBL
      A0A0R4IGP6, A0A8M3ARR1
      Related
      ENSDARP00000132638.1, ENSDART00000170888.2
      Conserved Domains (2) summary
      cd00288
      Location:43 → 531
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:44 → 528
      pyruv_kin; pyruvate kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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