Ipo9 importin 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ipo9provided by MGI
Official Full Name: importin 9provided by MGI
Primary source: MGI:MGI:1918944
See related: Ensembl:ENSMUSG00000041879 AllianceGenome:MGI:1918944
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Imp9; Ranbp9; 0710008K06Rik
Summary: Enables histone binding activity. Acts upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including central nervous system and retina. Orthologous to human IPO9 (importin 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 30.3), limb E14.5 (RPKM 26.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.6 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (135310050..135358260, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (135382312..135430499, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the active maintenance of nuclear actin levels by importin 9 is required for maximal transcriptional activity
Title: Active maintenance of nuclear actin by importin 9 supports transcription.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI845704 (e-PCR)
- UniSTS:165107

RH126354 (e-PCR)
- UniSTS:163062

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone chaperone activity	ISO Inferred from Sequence Orthology more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in proteasome localization	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into nucleus	ISA Inferred from Sequence Alignment more info	PubMed
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein stabilization	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ribosome biogenesis	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: importin-9

Names: Ran binding protein 9; ran-binding protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357575.1 → NP_001344504.1 importin-9 isoform 2

Status: VALIDATED

Source sequence(s)

AC016814

UniProtKB/Swiss-Prot

Q91YE6, Q924M3, Q924M4

Conserved Domains (1) summary

cl27876
Location:3 → 776

Cse1; Cse1
NM_001357576.1 → NP_001344505.1 importin-9 isoform 3

Status: VALIDATED

Source sequence(s)

AC016814

UniProtKB/Swiss-Prot

Q91YE6, Q924M3, Q924M4

Conserved Domains (1) summary

COG5656
Location:192 → 749

SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
NM_001357577.1 → NP_001344506.1 importin-9 isoform 3

Status: VALIDATED

Source sequence(s)

AC016814

UniProtKB/Swiss-Prot

Q91YE6, Q924M3, Q924M4

Conserved Domains (1) summary

COG5656
Location:192 → 749

SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
NM_001357578.1 → NP_001344507.1 importin-9 isoform 4

Status: VALIDATED

Source sequence(s)

AC016814

Conserved Domains (1) summary

cl27876
Location:61 → 618

Cse1
NM_153774.1 → NP_722469.1 importin-9 isoform 1

Status: VALIDATED

Source sequence(s)

AC016814, BC056469, CD347972

Consensus CDS

CCDS35719.1

UniProtKB/Swiss-Prot

Q91YE6, Q924M3, Q924M4

UniProtKB/TrEMBL

E9QKZ2

Related

ENSMUSP00000036093.8, ENSMUST00000041023.14

Conserved Domains (3) summary

smart00913
Location:43 → 117

IBN_N; Importin-beta N-terminal domain

COG5656
Location:22 → 900

SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

sd00044
Location:420 → 459

HEAT; HEAT repeat [structural motif]

RNA

NR_151727.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC016814, AK161881, BB851521, BC056469, BM947606, CB245332, CD741683

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

135310050..135358260 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163945.1 → XP_036019838.1 importin-9 isoform X1

UniProtKB/Swiss-Prot

Q91YE6, Q924M3, Q924M4

Conserved Domains (1) summary

COG5657
Location:34 → 812

CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
XM_006529437.2 → XP_006529500.1 importin-9 isoform X2

See identical proteins and their annotated locations for XP_006529500.1

UniProtKB/Swiss-Prot

Q91YE6, Q924M3, Q924M4

Conserved Domains (1) summary

COG5656
Location:192 → 749

SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
XM_036163950.1 → XP_036019843.1 importin-9 isoform X3

Conserved Domains (1) summary

COG5656
Location:192 → 749

SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]