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    Kif23 kinesin family member 23 [ Mus musculus (house mouse) ]

    Gene ID: 71819, updated on 8-May-2024

    Summary

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    Official Symbol
    Kif23provided by MGI
    Official Full Name
    kinesin family member 23provided by MGI
    Primary source
    MGI:MGI:1919069
    See related
    Ensembl:ENSMUSG00000032254 AllianceGenome:MGI:1919069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CHO1; Knsl5; MKLP1; MKLP-1; 3110001D19Rik
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including mitotic cytokinesis; mitotic spindle midzone assembly; and positive regulation of cytokinesis. Predicted to act upstream of or within cell division. Located in intercellular bridge. Is expressed in several structures, including alimentary system; hindbrain; nephrogenic zone; olfactory epithelium; and ventricular layer. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 14.9), liver E14 (RPKM 11.3) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kif23 in Genome Data Viewer
    Location:
    9 B; 9 33.5 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (61824559..61854078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (61917277..61946810, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6748 Neighboring gene predicted gene, 35058 Neighboring gene ribosomal protein lateral stalk subunit P1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61794519-61794820 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61795876-61796177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:61808677-61808878 Neighboring gene STARR-positive B cell enhancer ABC_E5075 Neighboring gene progestin and adipoQ receptor family member V Neighboring gene predicted gene, 35152 Neighboring gene glucuronyl C5-epimerase Neighboring gene microRNA 5133

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KIF23 Promotes Gastric Cancer by Stimulating Cell Proliferation. Li XL, et al. Dis Markers, 2019. PMID 31007778, Free PMC Article
    2. Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III. Vikberg AL, et al. Blood Cells Mol Dis, 2020 Nov. PMID 32818800
    3. CHO1, a mammalian kinesin-like protein, interacts with F-actin and is involved in the terminal phase of cytokinesis. Kuriyama R, et al. J Cell Biol, 2002 Mar 4. PMID 11877456, Free PMC Article
    4. Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis. Okamoto A, et al. Cell Cycle, 2015. PMID 25786116, Free PMC Article
    5. An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Iltzsche F, et al. Oncogene, 2017 Jan 5. PMID 27212033

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of KIF23 alleviates the progression of asthma by inhibiting pyroptosis.
      Title: Knockdown of KIF23 alleviates the progression of asthma by inhibiting pyroptosis.
    2. Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III.
      Title: Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III.
    3. Kif23 up-regulation promotes cell proliferation and gastric cancer progression.
      Title: KIF23 Promotes Gastric Cancer by Stimulating Cell Proliferation.
    4. depletion of KIF23 inhibited lung tumor formation in vivo, similar to what is seen with deletion of MMB. In vitro, the depletion of KIF23 in lung cancer cell lines showed strong anti-proliferative activity, which was accompanied by apoptosis in a subset of cell lines.
      Title: An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle midzone assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of centralspindlin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF23
    Names
    kinesin-like 5 (mitotic kinesin-like protein 1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405055.1 → NP_001391984.1  kinesin-like protein KIF23 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC151969

    2. NM_001405056.1 → NP_001391985.1  kinesin-like protein KIF23 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC151969

    3. NM_001405057.1 → NP_001391986.1  kinesin-like protein KIF23 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC151969

    4. NM_024245.5 → NP_077207.3  kinesin-like protein KIF23 isoform 2

      See identical proteins and their annotated locations for NP_077207.3

      Status: VALIDATED

      Source sequence(s)
      AC151969
      Consensus CDS
      CCDS40662.1
      UniProtKB/Swiss-Prot
      E9Q5G3, Q80V30, Q99PT8
      Related
      ENSMUSP00000034815.8, ENSMUST00000034815.9
      Conserved Domains (4) summary
      cd01368
      Location:24 → 434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31 → 436
      Kinesin; Kinesin motor domain
      pfam08702
      Location:498 → 603
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam16540
      Location:797 → 896
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      61824559..61854078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244618.2 → XP_030100478.1  kinesin-like protein KIF23 isoform X4

      Conserved Domains (3) summary
      pfam05483
      Location:504 → 690
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd01368
      Location:24 → 448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:707 → 809
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    2. XM_006511453.5 → XP_006511516.1  kinesin-like protein KIF23 isoform X2

      Conserved Domains (3) summary
      pfam05483
      Location:504 → 690
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd01368
      Location:24 → 448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:811 → 913
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q5G3.1 GenPept UniProtKB/Swiss-Prot:E9Q5G3

    Gene LinkOut

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