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    Wtap WT1 associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499020, updated on 2-May-2024

    Summary

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    Official Symbol
    Wtapprovided by RGD
    Official Full Name
    WT1 associated proteinprovided by RGD
    Primary source
    RGD:1563824
    See related
    Ensembl:ENSRNOG00000019091 AllianceGenome:RGD:1563824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563824
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in mRNA methylation and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm; nuclear membrane; and nuclear speck. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Orthologous to human WTAP (WT1 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 300.6), Spleen (RPKM 223.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wtap in Genome Data Viewer
    Location:
    1q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50070973..50096074)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47665965..47691067)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47942500..47967633)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690969 Neighboring gene ATP synthase F1 subunit gamma, pseudogene 1 Neighboring gene superoxide dismutase 2 Neighboring gene uncharacterized LOC102553528 Neighboring gene acetyl-CoA acetyltransferase, cytosolic-like Neighboring gene acetyl-CoA acetyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling. Wang H, et al. Apoptosis, 2023 Jun. PMID 36894806
    2. SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function. Du Y, et al. Nucleic Acids Res, 2018 Jun 1. PMID 29506078, Free PMC Article
    3. Interactions, localization, and phosphorylation of the m(6)A generating METTL3-METTL14-WTAP complex. Schöller E, et al. RNA, 2018 Apr. PMID 29348140, Free PMC Article
    4. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Liu J, et al. Nat Chem Biol, 2014 Feb. PMID 24316715, Free PMC Article
    5. The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Niksic M, et al. Hum Mol Genet, 2004 Feb 15. PMID 14681305

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling.
      Title: m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA-splicing regulator WTAP
    Names
    Wilms tumor 1 associated protein
    Wilms' tumour 1-associating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113542.1 → NP_001107014.1  pre-mRNA-splicing regulator WTAP isoform a

      See identical proteins and their annotated locations for NP_001107014.1

      Status: VALIDATED

      Source sequence(s)
      AA900399, CK478322, CO561762, DV714133
      UniProtKB/TrEMBL
      A0A8I5XW36, D3ZPY0
      Related
      ENSRNOP00000025936.5, ENSRNOT00000025936.8
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 222
      Wtap; WTAP/Mum2p family

    2. NM_001113543.1 → NP_001107015.1  pre-mRNA-splicing regulator WTAP isoform b

      See identical proteins and their annotated locations for NP_001107015.1

      Status: VALIDATED

      Source sequence(s)
      BQ202659, CK478322, CV108433, CX570823
      UniProtKB/TrEMBL
      A0A0G2K2U2, A6KP27
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 150
      Wtap; WTAP/Mum2p family

    3. NM_001113544.1 → NP_001107016.1  pre-mRNA-splicing regulator WTAP isoform b

      See identical proteins and their annotated locations for NP_001107016.1

      Status: VALIDATED

      Source sequence(s)
      BQ202659, CB613741, CB613959, CX570823
      UniProtKB/TrEMBL
      A0A0G2K2U2, A6KP27
      Related
      ENSRNOP00000072376.1, ENSRNOT00000079312.2
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 150
      Wtap; WTAP/Mum2p family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      50070973..50096074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270739.1 → XP_063126809.1  pre-mRNA-splicing regulator WTAP isoform X3

    2. XM_006227892.5 → XP_006227954.1  pre-mRNA-splicing regulator WTAP isoform X1

      See identical proteins and their annotated locations for XP_006227954.1

      UniProtKB/TrEMBL
      A0A8I5XW36, D3ZPY0
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 222
      Wtap; WTAP/Mum2p family

    3. XM_039086894.2 → XP_038942822.1  pre-mRNA-splicing regulator WTAP isoform X3

      UniProtKB/TrEMBL
      A6KP27
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 150
      Wtap; WTAP/Mum2p family

    4. XM_006227893.4 → XP_006227955.1  pre-mRNA-splicing regulator WTAP isoform X1

      See identical proteins and their annotated locations for XP_006227955.1

      UniProtKB/TrEMBL
      A0A8I5XW36, D3ZPY0
      Related
      ENSRNOP00000077397.1
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 222
      Wtap; WTAP/Mum2p family

    5. XM_063270747.1 → XP_063126817.1  pre-mRNA-splicing regulator WTAP isoform X3

    6. XM_039086893.2 → XP_038942821.1  pre-mRNA-splicing regulator WTAP isoform X2

      UniProtKB/TrEMBL
      A6KP29
      Conserved Domains (1) summary
      pfam17098
      Location:1 → 65
      Wtap; WTAP/Mum2p family

    7. XM_039086890.2 → XP_038942818.1  pre-mRNA-splicing regulator WTAP isoform X2

      UniProtKB/TrEMBL
      A6KP29
      Conserved Domains (1) summary
      pfam17098
      Location:1 → 65
      Wtap; WTAP/Mum2p family
    Nucleotide Protein Strain
    Heading Accession and Version

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