Cd101 CD101 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd101provided by MGI
Official Full Name: CD101 antigenprovided by MGI
Primary source: MGI:MGI:2685862
See related: Ensembl:ENSMUSG00000086564 AllianceGenome:MGI:2685862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm734; Igsf2; Gm1016; EWI-101
Summary: Acts upstream of or within positive regulation of myeloid leukocyte differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human CD101 (CD101 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 1.1), lung adult (RPKM 0.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 43.9 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (100899505..100936869, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (100992189..101029553, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Induction of Siglec-F[hi]CD101[hi] eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.
Title: Induction of Siglec-F(hi)CD101(hi) eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.
ur results connect the Cd101 haplotype-dependent protection from T1D to an anti-diabetogenic function of CD101-expressing Tregs and Gr1-positive myeloid cells and confirm the identity of Cd101 as Idd10.
Title: Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.
CD101 inhibits the expansion of colitogenic T cells.
Title: CD101 inhibits the expansion of colitogenic T cells.
A gene region (Idd10) previously shown to influence susceptibility to type 1 diabetes in the NOD mouse also influences an autoimmune disease involving a different tissue, the liver, which follows an infection with Novosphingobium aromaticivorans.
Title: Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity.
Further support is provided for the hypothesis that Cd101 is insulin-dependent diabetes susceptibility region 10 (Idd10); haplotype and expression analyses of novel Idd10 congenic strains are coupled to the development of a CD101 knockout mouse.
Title: Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.
of the eight genes found in the Idd10 region, the CD101 gene was selected as a candidate for Idd10 based on its function in humans and its polymorphism in the NOD strain of mice
Title: Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.
Cd101, but not Fcgr1, is responsible for the Idd10 effect
Title: Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of myeloid leukocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: immunoglobulin superfamily member 2

Names: EWI immunoglobulin subfamily member EWI-101; glu-Trp-Ile EWI motif-containing protein 101; immunoglobulin superfamily, member 2; leukocyte surface protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167906.2 → NP_001161378.1 immunoglobulin superfamily member 2 precursor

See identical proteins and their annotated locations for NP_001161378.1

Status: VALIDATED

Source sequence(s)

AL669872

Consensus CDS

CCDS51020.1

UniProtKB/Swiss-Prot

A8E0Y8, A8E0Y9

UniProtKB/TrEMBL

A0A0B4J1L8

Related

ENSMUSP00000116643.3, ENSMUST00000147399.9

Conserved Domains (5) summary

cd00096
Location:300 → 391

Ig; Immunoglobulin domain

smart00410
Location:29 → 142

IG_like; Immunoglobulin like

pfam00047
Location:421 → 515

ig; Immunoglobulin domain

pfam07686
Location:26 → 143

V-set; Immunoglobulin V-set domain

cl11960
Location:831 → 927

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

100899505..100936869 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001099332.2: Suppressed sequence

Description

NM_001099332.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.