U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Asb12 ankyrin repeat and SOCS box-containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 70392, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Asb12provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 12provided by MGI
    Primary source
    MGI:MGI:1917642
    See related
    Ensembl:ENSMUSG00000031204 AllianceGenome:MGI:1917642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asb-12; 2310036C05Rik
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB12 (ankyrin repeat and SOCS box containing 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 3.3), heart adult (RPKM 3.0) and 4 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Asb12 in Genome Data Viewer
    Location:
    X C3; X 41.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (94513125..94601610, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (95469527..95558004, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene APC membrane recruitment 1 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47573 Neighboring gene STARR-seq mESC enhancer starr_47574 Neighboring gene zinc finger, C4H2 domain containing Neighboring gene adenylosuccinate lyase pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Testis-enriched Asb12 is not required for spermatogenesis and fertility in mice. Zhang R, et al. Transl Androl Urol, 2022 Feb. PMID 35280661, Free PMC Article
    2. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
    3. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC130200

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ankyrin repeat and SOCS box protein 12
    Names
    ankyrin repeat and SOCS box-containing protein 12
    ankyrin repeat domain-containing SOCS box protein 12

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313743.1 → NP_001300672.1  ankyrin repeat and SOCS box protein 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AL671765, BC107257
      Consensus CDS
      CCDS30283.1
      UniProtKB/Swiss-Prot
      Q9D738
      UniProtKB/TrEMBL
      Q3KNI9
      Conserved Domains (4) summary
      PHA02875
      Location:25 → 259
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:66 → 94
      ANK; ANK repeat [structural motif]
      pfam07525
      Location:268 → 306
      SOCS_box; SOCS box
      pfam12796
      Location:68 → 159
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_080858.3 → NP_543134.1  ankyrin repeat and SOCS box protein 12

      See identical proteins and their annotated locations for NP_543134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AL671765
      Consensus CDS
      CCDS30283.1
      UniProtKB/Swiss-Prot
      Q9D738
      UniProtKB/TrEMBL
      Q3KNI9
      Related
      ENSMUSP00000033549.3, ENSMUST00000033549.3
      Conserved Domains (4) summary
      PHA02875
      Location:25 → 259
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:66 → 94
      ANK; ANK repeat [structural motif]
      pfam07525
      Location:268 → 306
      SOCS_box; SOCS box
      pfam12796
      Location:68 → 159
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      94513125..94601610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247674.4 → XP_011245976.1  ankyrin repeat and SOCS box protein 12 isoform X1

      See identical proteins and their annotated locations for XP_011245976.1

      UniProtKB/Swiss-Prot
      Q9D738
      UniProtKB/TrEMBL
      Q3KNI9
      Conserved Domains (4) summary
      PHA02875
      Location:25 → 259
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:66 → 94
      ANK; ANK repeat [structural motif]
      pfam07525
      Location:268 → 306
      SOCS_box; SOCS box
      pfam12796
      Location:68 → 159
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D738.1 GenPept UniProtKB/Swiss-Prot:Q9D738

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous