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    Ralgps1 Ral GEF with PH domain and SH3 binding motif 1 [ Mus musculus (house mouse) ]

    Gene ID: 241308, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ralgps1provided by MGI
    Official Full Name
    Ral GEF with PH domain and SH3 binding motif 1provided by MGI
    Primary source
    MGI:MGI:1922008
    See related
    Ensembl:ENSMUSG00000038831 AllianceGenome:MGI:1922008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RALGEF2; RALGPS1A; RalGEF 2; mKIAA0351; 5830418G11Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Ral protein signal transduction. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human RALGPS1 (Ral GEF with PH domain and SH3 binding motif 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 23.6), whole brain E14.5 (RPKM 21.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ralgps1 in Genome Data Viewer
    Location:
    2 B; 2 22.25 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33023431..33261569, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33133419..33371499, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1586 Neighboring gene solute carrier family 2, (facilitated glucose transporter), member 8 Neighboring gene GTPase activating RANGAP domain-like 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32888039-32888233 Neighboring gene STARR-seq mESC enhancer starr_04227 Neighboring gene STARR-seq mESC enhancer starr_04229 Neighboring gene STARR-positive B cell enhancer ABC_E2614 Neighboring gene STARR-positive B cell enhancer ABC_E2615 Neighboring gene predicted gene 13528 Neighboring gene predicted gene, 23546 Neighboring gene angiopoietin-like 2 Neighboring gene STARR-seq mESC enhancer starr_04235 Neighboring gene STARR-seq mESC enhancer starr_04237 Neighboring gene STARR-seq mESC enhancer starr_04239 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene predicted gene 13536 Neighboring gene zinc finger and BTB domain containing 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras. Omidvar N, et al. Mol Cell Biol, 2006 May. PMID 16648489, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ralgps1 is both necessary and sufficient for the inhibition of myeloid differentiation by Ras.
      Title: Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Ral protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-specific guanine nucleotide-releasing factor RalGPS1
    Names
    Ral guanine nucleotide exchange factor RalGPS1A
    ral GEF with PH domain and SH3-binding motif 1
    ral guanine nucleotide exchange factor 2
    ralA exchange factor RalGPS1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290570.1 → NP_001277499.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and also lacks two exons and uses an alternate splice site that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK129123, BC072656, CJ112478
      Consensus CDS
      CCDS71031.1
      UniProtKB/TrEMBL
      A0A0A0MQE4
      Related
      ENSMUSP00000048451.7, ENSMUST00000042615.13
      Conserved Domains (3) summary
      smart00147
      Location:38 → 271
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:373 → 488
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:372 → 483
      PH; PH domain

    2. NM_001290572.1 → NP_001277501.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AK017939, BC072656, CJ112478
      Consensus CDS
      CCDS79779.1
      UniProtKB/TrEMBL
      A0A0A0MQE4
      Related
      ENSMUSP00000118363.3, ENSMUST00000131298.7
      Conserved Domains (2) summary
      smart00147
      Location:46 → 288
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:391 → 506
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    3. NM_175211.5 → NP_780420.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform a

      See identical proteins and their annotated locations for NP_780420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK076767, BC072656, CJ112478
      Consensus CDS
      CCDS15939.1
      UniProtKB/Swiss-Prot
      A2AR50, A2AR51, A2AR52, Q6GQS4, Q6ZQD2, Q8BVR9, Q8C1I2
      UniProtKB/TrEMBL
      A0A0A0MQE4
      Related
      ENSMUSP00000088563.3, ENSMUST00000091039.5
      Conserved Domains (2) summary
      smart00147
      Location:46 → 288
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:461 → 576
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      33023431..33261569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498037.4 → XP_006498100.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X7

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      smart00147
      Location:46 → 288
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:390 → 505
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    2. XM_006498033.4 → XP_006498096.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X2

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      smart00147
      Location:46 → 288
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:460 → 575
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    3. XM_030251025.2 → XP_030106885.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X9

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      smart00147
      Location:21 → 252
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:354 → 469
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    4. XM_006498035.4 → XP_006498098.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X4

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      smart00147
      Location:21 → 252
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:425 → 540
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    5. XM_006498034.5 → XP_006498097.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      smart00147
      Location:38 → 271
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:444 → 559
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    6. XM_030251023.2 → XP_030106883.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X8

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      smart00147
      Location:38 → 271
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:374 → 489
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    7. XM_036161819.1 → XP_036017712.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X11

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      cd13310
      Location:329 → 444
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:46 → 227
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    8. XM_036161817.1 → XP_036017710.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X10

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      cd13310
      Location:330 → 445
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:46 → 227
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    9. XM_036161812.1 → XP_036017705.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X5

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      cd13310
      Location:400 → 515
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:46 → 227
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    10. XM_030251028.1 → XP_030106888.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X13

      Conserved Domains (2) summary
      cd13310
      Location:250 → 365
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1 → 147
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    11. XM_030251026.2 → XP_030106886.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X12

      Conserved Domains (2) summary
      cd13310
      Location:320 → 435
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1 → 147
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    12. XM_030251022.2 → XP_030106882.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X6

      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      smart00147
      Location:46 → 288
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:391 → 506
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    13. XM_006498032.4 → XP_006498095.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X1

      See identical proteins and their annotated locations for XP_006498095.1

      UniProtKB/Swiss-Prot
      A2AR50, A2AR51, A2AR52, Q6GQS4, Q6ZQD2, Q8BVR9, Q8C1I2
      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      smart00147
      Location:46 → 288
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:461 → 576
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    14. XM_030251011.1 → XP_030106871.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X1

      UniProtKB/Swiss-Prot
      A2AR50, A2AR51, A2AR52, Q6GQS4, Q6ZQD2, Q8BVR9, Q8C1I2
      UniProtKB/TrEMBL
      A0A0A0MQE4
      Conserved Domains (2) summary
      smart00147
      Location:46 → 288
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:461 → 576
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    RNA

    1. XR_004940327.1 RNA Sequence

    2. XR_003952801.2 RNA Sequence

    3. XR_374090.5 RNA Sequence

    4. XR_374091.4 RNA Sequence

    5. XR_374089.5 RNA Sequence

    6. XR_003952804.2 RNA Sequence

    7. XR_374092.5 RNA Sequence

    8. XR_003952802.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AR50.2 GenPept UniProtKB/Swiss-Prot:A2AR50

    Gene LinkOut

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