Kcna7 potassium voltage-gated channel, shaker-related subfamily, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcna7provided by MGI
Official Full Name: potassium voltage-gated channel, shaker-related subfamily, member 7provided by MGI
Primary source: MGI:MGI:96664
See related: Ensembl:ENSMUSG00000038201 AllianceGenome:MGI:96664
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kv1.7
Summary: Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in heart and heart ventricle. Orthologous to human KCNA7 (potassium voltage-gated channel subfamily A member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 6.7), heart adult (RPKM 2.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.3 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45055384..45060806)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45405960..45411382)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kv1.7 channels from mouse heart muscle have two putative translation initiation start sites that generate two channel isoforms with different functional characteristics, mKv1.7L (489 aa) and a shorter mKv1.7S (457 aa).
Title: Molecular and Functional Differences between Heart mKv1.7 Channel Isoforms.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 7

Names: potassium voltage-gated channel, shaker-related subfamily, member 7; potassium voltage gated channel, shaker related subfamily, member 7; voltage-gated potassium channel subunit Kv1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010596.2 → NP_034726.2 potassium voltage-gated channel subfamily A member 7

See identical proteins and their annotated locations for NP_034726.2

Status: VALIDATED

Source sequence(s)

AC151602

Consensus CDS

CCDS39951.1

UniProtKB/Swiss-Prot

O70259, Q17ST2

Related

ENSMUSP00000103403.2, ENSMUST00000107774.3

Conserved Domains (4) summary

smart00225
Location:47 → 130

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:228 → 437

Ion_trans; Ion transport protein

pfam02214
Location:47 → 137

BTB_2; BTB/POZ domain

pfam07885
Location:352 → 431

Ion_trans_2; Ion channel