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    Satb2 special AT-rich sequence binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 212712, updated on 28-May-2024

    Summary

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    Official Symbol
    Satb2provided by MGI
    Official Full Name
    special AT-rich sequence binding protein 2provided by MGI
    Primary source
    MGI:MGI:2679336
    See related
    Ensembl:ENSMUSG00000038331 AllianceGenome:MGI:2679336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BAP002; mKIAA1034
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within several processes, including generation of neurons; regulation of transcription by RNA polymerase II; and skeletal system development. Located in nucleus. Part of histone deacetylase complex and transcription regulator complex. Is expressed in several structures, including 1st branchial arch; cerebral cortex; facial prominence; genitourinary system; and limb. Used to study isolated cleft palate. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB2 (SATB homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 11.8), CNS E18 (RPKM 11.0) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Satb2 in Genome Data Viewer
    Location:
    1 C1.3; 1 28.72 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (56833145..57019350, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (56793981..56981190, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53554 Neighboring gene STARR-seq mESC enhancer starr_00966 Neighboring gene STARR-seq mESC enhancer starr_00967 Neighboring gene STARR-seq mESC enhancer starr_00969 Neighboring gene heat shock transcription factor, Y-linked 2 Neighboring gene STARR-seq mESC enhancer starr_00971 Neighboring gene STARR-seq mESC enhancer starr_00972 Neighboring gene STARR-seq mESC enhancer starr_00973 Neighboring gene predicted gene, 51624 Neighboring gene STARR-seq mESC enhancer starr_00974 Neighboring gene STARR-seq mESC enhancer starr_00975 Neighboring gene RIKEN cDNA 9130024F11 gene Neighboring gene predicted gene, 38484 Neighboring gene RIKEN cDNA 1700126A01 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Satb2 regulates proliferation and nuclear integrity of pre-osteoblasts. Dowrey T, et al. Bone, 2019 Oct. PMID 31325654, Free PMC Article
    2. Satb2 ablation decreases PTZ-induced seizure susceptibility and pyramidal neuronal excitability. Li Y, et al. Brain Res, 2018 Sep 15. PMID 29750936
    3. Satb2(Cre/+) mouse as a tool to investigate cell fate determination in the developing neocortex. Ambrozkiewicz MC, et al. J Neurosci Methods, 2017 Nov 1. PMID 28782628
    4. Satb2 determines miRNA expression and long-term memory in the adult central nervous system. Jaitner C, et al. Elife, 2016 Nov 29. PMID 27897969, Free PMC Article
    5. SATB2-associated syndrome presenting with Rett-like phenotypes. Lee JS, et al. Clin Genet, 2016 Jun. PMID 26596517

    See all (395) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes.
      Title: In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes.
    2. Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain.
      Title: Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain.
    3. MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex.
      Title: MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex.
    4. Satb2 Regulates EphA7 to Control Soma Spacing and Self-Avoidance of Cortical Pyramidal Neurons.
      Title: Satb2 Regulates EphA7 to Control Soma Spacing and Self-Avoidance of Cortical Pyramidal Neurons.
    5. A eutherian-specific microRNA controls the translation of Satb2 in a model of cortical differentiation.
      Title: A eutherian-specific microRNA controls the translation of Satb2 in a model of cortical differentiation.
    6. Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.
      Title: Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.
    7. Role of Satb1 and Satb2 Transcription Factors in the Glutamate Receptors Expression and Ca(2+) Signaling in the Cortical Neurons In Vitro.
      Title: Role of Satb1 and Satb2 Transcription Factors in the Glutamate Receptors Expression and Ca(2+) Signaling in the Cortical Neurons In Vitro.
    8. Satb2 is required for the regionalization of retrosplenial cortex.
      Title: Satb2 is required for the regionalization of retrosplenial cortex.
    9. Special AT-rich sequence-binding protein 2 (Satb2) synergizes with Bmp9 and is essential for osteo/odontogenic differentiation of mouse incisor mesenchymal stem cells.
      Title: Special AT-rich sequence-binding protein 2 (Satb2) synergizes with Bmp9 and is essential for osteo/odontogenic differentiation of mouse incisor mesenchymal stem cells.
    10. MicroRNA-31 regulates dental epithelial cell proliferation by targeting Satb2.
      Title: MicroRNA-31 regulates dental epithelial cell proliferation by targeting Satb2.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoblast development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoblast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding protein SATB2
    Names
    KIAA1034-like DNA binding protein
    two cut domains-containing homeodomain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358580.2 → NP_001345509.1  DNA-binding protein SATB2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101777, AC131072
      Consensus CDS
      CCDS14965.1
      UniProtKB/Swiss-Prot
      Q8VI24
      UniProtKB/TrEMBL
      H3BKH3, Q546B3
      Conserved Domains (4) summary
      smart00389
      Location:614 → 671
      HOX; Homeodomain
      cd11585
      Location:60 → 155
      SATB1_N; N-terminal domain of SATB1 and similar proteins
      pfam02376
      Location:481 → 551
      CUT; CUT domain
      pfam16557
      Location:166 → 232
      CUTL; CUT1-like DNA-binding domain of SATB

    2. NM_001358581.2 → NP_001345510.1  DNA-binding protein SATB2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101777, AC131072
      Consensus CDS
      CCDS14965.1
      UniProtKB/Swiss-Prot
      Q8VI24
      UniProtKB/TrEMBL
      H3BKH3, Q546B3
      Conserved Domains (4) summary
      smart00389
      Location:614 → 671
      HOX; Homeodomain
      cd11585
      Location:60 → 155
      SATB1_N; N-terminal domain of SATB1 and similar proteins
      pfam02376
      Location:481 → 551
      CUT; CUT domain
      pfam16557
      Location:166 → 232
      CUTL; CUT1-like DNA-binding domain of SATB

    3. NM_001420844.1 → NP_001407773.1  DNA-binding protein SATB2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101777, AC131072

    4. NM_001420845.1 → NP_001407774.1  DNA-binding protein SATB2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101777, AC131072
      UniProtKB/Swiss-Prot
      Q8VI24
      UniProtKB/TrEMBL
      Q546B3

    5. NM_139146.3 → NP_631885.1  DNA-binding protein SATB2 isoform 1

      See identical proteins and their annotated locations for NP_631885.1

      Status: VALIDATED

      Source sequence(s)
      AC101777, AC131072
      Consensus CDS
      CCDS14965.1
      UniProtKB/Swiss-Prot
      Q8VI24
      UniProtKB/TrEMBL
      H3BKH3, Q546B3
      Related
      ENSMUSP00000110057.4, ENSMUST00000114415.10
      Conserved Domains (4) summary
      smart00389
      Location:614 → 671
      HOX; Homeodomain
      cd11585
      Location:60 → 155
      SATB1_N; N-terminal domain of SATB1 and similar proteins
      pfam02376
      Location:481 → 551
      CUT; CUT domain
      pfam16557
      Location:166 → 232
      CUTL; CUT1-like DNA-binding domain of SATB

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      56833145..57019350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495827.5 → XP_006495890.1  DNA-binding protein SATB2 isoform X1

      See identical proteins and their annotated locations for XP_006495890.1

      UniProtKB/TrEMBL
      H3BKH3
      Conserved Domains (4) summary
      smart00389
      Location:621 → 678
      HOX; Homeodomain
      cd11585
      Location:67 → 162
      SATB1_N; N-terminal domain of SATB1 and similar proteins
      pfam02376
      Location:484 → 563
      CUT; CUT domain
      pfam16557
      Location:169 → 239
      CUTL; CUT1-like DNA-binding domain of SATB

    2. XM_036163326.1 → XP_036019219.1  DNA-binding protein SATB2 isoform X2

      UniProtKB/TrEMBL
      H3BKH3
      Conserved Domains (4) summary
      smart00389
      Location:556 → 613
      HOX; Homeodomain
      cd11585
      Location:2 → 97
      SATB1_N; N-terminal domain of SATB1 and similar proteins
      pfam02376
      Location:419 → 498
      CUT; CUT domain
      pfam16557
      Location:104 → 174
      CUTL; CUT1-like DNA-binding domain of SATB

    3. XM_030252735.2 → XP_030108595.1  DNA-binding protein SATB2 isoform X1

      UniProtKB/TrEMBL
      H3BKH3
      Conserved Domains (4) summary
      smart00389
      Location:621 → 678
      HOX; Homeodomain
      cd11585
      Location:67 → 162
      SATB1_N; N-terminal domain of SATB1 and similar proteins
      pfam02376
      Location:484 → 563
      CUT; CUT domain
      pfam16557
      Location:169 → 239
      CUTL; CUT1-like DNA-binding domain of SATB
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VI24.1 GenPept UniProtKB/Swiss-Prot:Q8VI24

    Gene LinkOut

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