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    Asb11 ankyrin repeat and SOCS box-containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 68854, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Asb11provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 11provided by MGI
    Primary source
    MGI:MGI:1916104
    See related
    Ensembl:ENSMUSG00000031382 AllianceGenome:MGI:1916104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110067L12Rik; 1600009D24Rik
    Summary
    Predicted to be involved in positive regulation of protein catabolic process and protein ubiquitination. Predicted to be located in endoplasmic reticulum. Orthologous to human ASB11 (ankyrin repeat and SOCS box containing 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 25.8), genital fat pad adult (RPKM 17.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Asb11 in Genome Data Viewer
    Location:
    X F5; X 76.53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (163219976..163242166)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164436953..164459170)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48238 Neighboring gene vascular endothelial growth factor D Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:160844233-160844342 Neighboring gene STARR-seq mESC enhancer starr_48240 Neighboring gene STARR-positive B cell enhancer ABC_E269 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A Neighboring gene chromobox protein homolog 1-like Neighboring gene ankyrin repeat and SOCS box-containing 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
    2. Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Richard AF, et al. Dev Biol, 2011 Nov 15. PMID 21884692
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 11
    Names
    ASB-11
    ankyrin repeat and SOCS box-containing protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313737.1 → NP_001300666.1  ankyrin repeat and SOCS box protein 11 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK005404, BU757326
      Consensus CDS
      CCDS85827.1
      UniProtKB/Swiss-Prot
      A2AIH7, Q3UJ13, Q9CQ31, Q9D0V1
      Related
      ENSMUSP00000044637.5, ENSMUST00000036858.11
      Conserved Domains (5) summary
      cd00204
      Location:66 → 183
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:102 → 189
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:66 → 118
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:66 → 95
      ANK; ANK repeat [structural motif]
      cl02533
      Location:282 → 323
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    2. NM_026853.2 → NP_081129.1  ankyrin repeat and SOCS box protein 11 isoform 2

      See identical proteins and their annotated locations for NP_081129.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK004396, AK005404, AK078851, BU757326
      Consensus CDS
      CCDS30523.1
      UniProtKB/Swiss-Prot
      Q9CQ31
      Conserved Domains (3) summary
      sd00045
      Location:37 → 66
      ANK; ANK repeat [structural motif]
      cl02533
      Location:253 → 294
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:33 → 240
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      163219976..163242166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528972.5 → XP_006529035.2  ankyrin repeat and SOCS box protein 11 isoform X2

      Conserved Domains (3) summary
      sd00045
      Location:66 → 95
      ANK; ANK repeat [structural motif]
      cl02533
      Location:237 → 278
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:39 → 224
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006528971.5 → XP_006529034.2  ankyrin repeat and SOCS box protein 11 isoform X1

      Conserved Domains (3) summary
      PHA02874
      Location:69 → 243
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:129 → 157
      ANK; ANK repeat [structural motif]
      cl02533
      Location:246 → 287
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    3. XM_036162086.1 → XP_036017979.1  ankyrin repeat and SOCS box protein 11 isoform X3

      Related
      ENSMUSP00000033755.6, ENSMUST00000033755.6
      Conserved Domains (3) summary
      sd00045
      Location:37 → 66
      ANK; ANK repeat [structural motif]
      cl02533
      Location:253 → 294
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:33 → 240
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_030251494.2 → XP_030107354.1  ankyrin repeat and SOCS box protein 11 isoform X6

      Conserved Domains (3) summary
      sd00045
      Location:37 → 66
      ANK; ANK repeat [structural motif]
      cl02533
      Location:208 → 249
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:33 → 195
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_036162087.1 → XP_036017980.1  ankyrin repeat and SOCS box protein 11 isoform X5

      Conserved Domains (3) summary
      PHA02874
      Location:40 → 214
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:100 → 128
      ANK; ANK repeat [structural motif]
      cl02533
      Location:217 → 258
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    6. XM_006528974.5 → XP_006529037.1  ankyrin repeat and SOCS box protein 11 isoform X4

      Conserved Domains (3) summary
      sd00045
      Location:30 → 59
      ANK; ANK repeat [structural motif]
      cl02533
      Location:246 → 287
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:22 → 233
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ31.1 GenPept UniProtKB/Swiss-Prot:Q9CQ31

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