PWAR6 Prader Willi/Angelman region RNA 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PWAR6provided by HGNC
Official Full Name: Prader Willi/Angelman region RNA 6provided by HGNC
Primary source: HGNC:HGNC:49129
See related: AllianceGenome:HGNC:49129
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HBT8; PAR-6
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Genomic context

Location:: 15q11.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (25031873..25036490)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (22768530..22773147)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (25277020..25281637)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long Non-coding RNA Prader Willi/Angelman Region RNA 6 Suppresses Glioma Development by Modulating MicroRNA-106a-5p.
Title: Long Non-coding RNA Prader Willi/Angelman Region RNA 6 Suppresses Glioma Development by Modulating MicroRNA-106a-5p.
LncRNA PWAR6 regulates proliferation and migration by epigenetically silencing YAP1 in tumorigenesis of pancreatic ductal adenocarcinoma.
Title: LncRNA PWAR6 regulates proliferation and migration by epigenetically silencing YAP1 in tumorigenesis of pancreatic ductal adenocarcinoma.
PWAR6 interacts with miR106a5p to regulate the osteogenic differentiation of human periodontal ligament stem cells.
Title: PWAR6 interacts with miR‑106a‑5p to regulate the osteogenic differentiation of human periodontal ligament stem cells.
We used allele specific expression in lymphoblastoid cell lines from 306 Hutterites related in a single pedigree to provide formal evidence for parent of origin effects. Our approach identified two putative novel imprinted genes, PXDC1 and PWAR6, with asymmetrical parent of origin gene expression.
Title: Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Markers

WI-13791 (e-PCR)
- UniSTS:81446

RH77804 (e-PCR)
- UniSTS:56715

D15S612E (e-PCR)
- UniSTS:149959

WI-15655 (e-PCR)
- UniSTS:38629

Clone Names

FLJ33569, FLJ36996, FLJ39265, DKFZp761I1912

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.