SULT2B1 sulfotransferase family 2B member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SULT2B1provided by HGNC
Official Full Name: sulfotransferase family 2B member 1provided by HGNC
Primary source: HGNC:HGNC:11459
See related: Ensembl:ENSG00000088002 MIM:604125; AllianceGenome:HGNC:11459
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSST2; ARCI14
Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in esophagus (RPKM 55.8), skin (RPKM 46.5) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (48552172..48599427)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (51546347..51593563)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (49055429..49102684)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory response and delay atherosclerosis progression.
Title: Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory response and delay atherosclerosis progression.
Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1-mediated lipid metabolism.
Title: Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1-mediated lipid metabolism.
Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration.
Title: Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration.
The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1.
Title: The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1.
undetectable in nearly all castration-resistant prostate cancer metastases (73 visceral, 82 bone) from 50 autopsy cases
Title: Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer.
The abundant SULT2B1 expression in normal gastric epithelium might maintain epithelial function via the PI3K/AKT signaling pathway.
Title: Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent.
SULT2B1b expression enhances resistance to TNF and may promote prostate cancer.
Title: Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer.
Data suggest therapeutic approaches to decrease sulphotransferase 2B1b (SULT2B1b) expression might be potentially beneficial for coronary artery disease (CAD) prevention by decreasing intracellular cholesterol.
Title: SULT2B1b inhibits reverse cholesterol transport and promotes cholesterol accumulation and inflammation in lymphocytes from AMI patients with low LDL-C levels.
SULT2B1b inversely correlates with prostate cancer status, with the highest level in the normal epithelium and lowest in the advanced metastatic prostate cancer. Furthermore, SULT2B1b is mostly located within the luminal layer of the prostate epithelium, suggesting that it may be implicated in luminal differentiation.
Title: Distinct expression patterns of SULT2B1b in human prostate epithelium.
Sulfotransferase 2B1b (SULT2B1b) interference attenuated the invasion abilities of human hepatocarcinoma BEL-7402cells. SULT2B1b interference inhibited the activation of the beta-catenin/MMP-7 pathway.
Title: SULT2B1b promotes epithelial-mesenchymal transition through activation of the β-catenin/MMP7 pathway in hepatocytes.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Ichthyosis, congenital, autosomal recessive 14 MedGen: C4539754 OMIM: 617571 GeneReviews: Autosomal Recessive Congenital Ichthyosis	Compare labs

EBI GWAS Catalog

Description
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:9484

GDB:434012 (e-PCR)
- UniSTS:157204

L17705 (e-PCR)
- UniSTS:66091

GDB:631802 (e-PCR)
- UniSTS:158429

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cholesterol binding	IDA Inferred from Direct Assay more info	PubMed
enables cholesterol sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small molecule binding	EXP Inferred from Experiment more info	PubMed
enables steroid hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables steroid sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in steroid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sulfotransferase 2B1

Names: ST2B1; alcohol sulfotransferase; hydroxysteroid sulfotransferase 2; hydroxysteroid sulfotransferase SULT2B1a; sulfotransferase family, cytosolic, 2B, member 1

NP_004596.2

EC 2.8.2.2

NP_814444.1

EC 2.8.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029063.1 RefSeqGene

Range

5001..52252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004605.2 → NP_004596.2 sulfotransferase 2B1 isoform a

See identical proteins and their annotated locations for NP_004596.2

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as SULT2B1a, differs in the 5' UTR and in the coding region when compared to variant 2. The resulting protein (isoform a) has a shorter and distinct N-terminus compared to isoform b.

Source sequence(s)

U92314

Consensus CDS

CCDS12724.1

UniProtKB/Swiss-Prot

O00204

Related

ENSP00000312880.3, ENST00000323090.4

Conserved Domains (1) summary

pfam00685
Location:45 → 290

Sulfotransfer_1; Sulfotransferase domain
NM_177973.2 → NP_814444.1 sulfotransferase 2B1 isoform b

See identical proteins and their annotated locations for NP_814444.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) is also known as SULT2B1b. It is the predominant transcript and it encodes the longer protein (isoform b).

Source sequence(s)

AC008403

Consensus CDS

CCDS12723.1

UniProtKB/Swiss-Prot

O00204, O00205, O75814

Related

ENSP00000201586.2, ENST00000201586.7

Conserved Domains (1) summary

pfam00685
Location:60 → 305

Sulfotransfer_1; Sulfotransferase domain