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    TSGA10IP testis specific 10 interacting protein [ Homo sapiens (human) ]

    Gene ID: 254187, updated on 7-Apr-2024

    Summary

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    Official Symbol
    TSGA10IPprovided by HGNC
    Official Full Name
    testis specific 10 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:26555
    See related
    Ensembl:ENSG00000175513 AllianceGenome:HGNC:26555
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM161C
    Summary
    Predicted to be involved in cilium organization. Predicted to be active in photoreceptor connecting cilium. Predicted to colocalize with ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 2.7) See more
    Orthologs
    mouse all
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    Genomic context

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    See TSGA10IP in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65945480..65959966)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65938560..65953047)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65712951..65727437)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:65685650-65686569 and GRCh37_chr11:65686570-65687490 Neighboring gene chromosome 11 open reading frame 68 Neighboring gene DR1 associated protein 1 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3343 Neighboring gene NANOG hESC enhancer GRCh37_chr11:65704708-65705232 Neighboring gene uncharacterized LOC105369350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65708489-65708988 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:65708959-65709182 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65729063-65729850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65733572-65734072 Neighboring gene spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. Abraham CG, et al. Cell Rep, 2018 Sep 18. PMID 30232004, Free PMC Article
    2. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Hill SJ, et al. Genes Dev, 2014 Sep 1. PMID 25184681, Free PMC Article
    3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
    4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32880, MGC120465, MGC120466, MGC120468

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in photoreceptor connecting cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific protein 10-interacting protein
    Names
    tsga10-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395491.1 → NP_001382420.1  testis-specific protein 10-interacting protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AP006287, KF459671

    2. NM_001395492.1 → NP_001382421.1  testis-specific protein 10-interacting protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AP006287, KF459671

    3. NM_001395493.1 → NP_001382422.1  testis-specific protein 10-interacting protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AP006287, KF459671

    4. NM_001395494.1 → NP_001382423.1  testis-specific protein 10-interacting protein isoform d

      Status: VALIDATED

      Source sequence(s)
      AP006287, KF459671

    5. NM_001395495.1 → NP_001382424.1  testis-specific protein 10-interacting protein isoform e

      Status: VALIDATED

      Source sequence(s)
      AP006287, KF459671

    6. NM_152762.3 → NP_689975.2  testis-specific protein 10-interacting protein isoform b

      See identical proteins and their annotated locations for NP_689975.2

      Status: VALIDATED

      Source sequence(s)
      AP006287, KF459671
      Consensus CDS
      CCDS66138.1
      UniProtKB/Swiss-Prot
      Q3SXZ9, Q3SY00, Q3SY01, Q96M26
      Related
      ENSP00000484252.1, ENST00000532620.6

    RNA

    1. NR_172563.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP006287, KF459671
      Related
      ENST00000534740.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65945480..65959966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426706.1 → XP_047282662.1  testis-specific protein 10-interacting protein isoform X1

    RNA

    1. XR_949858.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65938560..65953047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368298.1 → XP_054224273.1  testis-specific protein 10-interacting protein isoform X1

    RNA

    1. XR_008488375.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SY00.2 GenPept UniProtKB/Swiss-Prot:Q3SY00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials