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    aqp-5 AQuaPorin or aquaglyceroporin related [ Caenorhabditis elegans ]

    Gene ID: 183221, updated on 12-Jun-2024

    Summary

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    Gene symbol
    aqp-5
    Gene description
    AQuaPorin or aquaglyceroporin related
    Locus tag
    CELE_C35A5.1
    See related
    AllianceGenome:WB:WBGene00000173
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable water channel activity. Predicted to be involved in transmembrane transport and water transport. Located in cell surface. Is expressed in IL1 neuron and pharyngeal neurons. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See aqp-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (10491743..10493256)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Sodium/calcium exchanger membrane region domain-containing protein Neighboring gene ncRNA Neighboring gene glucuronosyltransferase Neighboring gene Major sperm protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of C. elegans deletion mutants following ENU mutagenesis and thermostable restriction enzyme PCR screening. Huang CG, et al. Mol Biotechnol, 2006 Jan. PMID 16382185
    2. Functional analysis of the aquaporin gene family in Caenorhabditis elegans. Huang CG, et al. Am J Physiol Cell Physiol, 2007 May. PMID 17229810
    3. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Dorfman M, et al. Genetics, 2009 Aug. PMID 19528325, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AQuaPorin or aquaglyceroporin related
    NP_505691.2
    • Product from WormBase gene class aqp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10491743..10493256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073290.5 → NP_505691.2  AQuaPorin or aquaglyceroporin related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505691.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18469
      Conserved Domains (1) summary
      cl00200
      Location:45 → 307
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Nucleotide Protein
    Heading Accession and Version

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