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    Akna AT-hook transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362530, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Aknaprovided by RGD
    Official Full Name
    AT-hook transcription factorprovided by RGD
    Primary source
    RGD:1308202
    See related
    Ensembl:ENSRNOG00000008005 AllianceGenome:RGD:1308202
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including epithelial to mesenchymal transition; neuroblast delamination; and neuroblast division in subventricular zone. Predicted to be located in cytosol; microtubule cytoskeleton; and nuclear lumen. Predicted to be active in centrosome. Orthologous to human AKNA (AT-hook transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 144.1), Spleen (RPKM 90.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akna in Genome Data Viewer
    Location:
    5q24
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (81792928..81839936, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (76777415..76824380, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (79184087..79232370, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene microRNA 455 Neighboring gene orosomucoid 1 Neighboring gene uncharacterized LOC102547858 Neighboring gene whirlin Neighboring gene H/ACA ribonucleoprotein complex subunit 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PKA/CREB and NF-κB pathway regulates AKNA transcription: A novel insight into T-2 toxin-induced inflammation and GH deficiency in GH3 cells. Liu X, et al. Toxicology, 2017 Dec 1. PMID 29079362
    2. Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Ma W, et al. Cell Res, 2011 Nov. PMID 21606955, Free PMC Article
    3. Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. Siddiqa A, et al. Nature, 2001 Mar 15. PMID 11268217
    4. The centrosome protein AKNA regulates neurogenesis via microtubule organization. Camargo Ortega G, et al. Nature, 2019 Mar. PMID 30787442
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in delamination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial to mesenchymal transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuroblast delamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuroblast delamination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuroblast division in subventricular zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuroblast division in subventricular zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microtubule organization protein AKNA
    Names
    AT-hook-containing transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108668.1 → NP_001102138.1  microtubule organization protein AKNA

      See identical proteins and their annotated locations for NP_001102138.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473978
      UniProtKB/TrEMBL
      A0A8I5ZL68, A6J7Y1, D3ZLV5
      Related
      ENSRNOP00000010515.5, ENSRNOT00000010516.6
      Conserved Domains (1) summary
      pfam12443
      Location:583 → 674
      AKNA; AT-hook-containing transcription factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      81792928..81839936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238257.5 → XP_006238319.1  microtubule organization protein AKNA isoform X1

      See identical proteins and their annotated locations for XP_006238319.1

      UniProtKB/TrEMBL
      A0A8I5ZL68, A6J7Y1, D3ZLV5
      Conserved Domains (1) summary
      pfam12443
      Location:583 → 674
      AKNA; AT-hook-containing transcription factor

    2. XM_063287937.1 → XP_063144007.1  microtubule organization protein AKNA isoform X1

      UniProtKB/TrEMBL
      A6J7Y1, D3ZLV5

    3. XM_063287938.1 → XP_063144008.1  microtubule organization protein AKNA isoform X2

    4. XM_039110253.2 → XP_038966181.1  microtubule organization protein AKNA isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZL68, A6J7Y1, D3ZLV5
      Conserved Domains (1) summary
      pfam12443
      Location:583 → 674
      AKNA; AT-hook-containing transcription factor

    5. XM_039110254.2 → XP_038966182.1  microtubule organization protein AKNA isoform X3

      Conserved Domains (1) summary
      pfam12443
      Location:583 → 674
      AKNA; AT-hook-containing transcription factor

    RNA

    1. XR_005504479.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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