Mtmr3 myotubularin related protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtmr3provided by RGD
Official Full Name: myotubularin related protein 3provided by RGD
Primary source: RGD:1310972
See related: Ensembl:ENSRNOG00000007120 AllianceGenome:RGD:1310972
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatase activity and protein phosphatase binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; phosphatidylinositol metabolic process; and regulation of phosphatidylinositol dephosphorylation. Predicted to be extrinsic component of membrane. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 209.4), Adrenal (RPKM 205.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (83564065..83684573, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (79340523..79460947, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (84701559..84820487, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BM386970 (e-PCR)
- UniSTS:261658

RH136875 (e-PCR)
- UniSTS:218964

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 5-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 5-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myotubularin-related protein 3

Names: phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase

NP_001012038.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_006251364.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_006251366.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_006251367.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_008768523.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_038947968.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_038947969.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_038947970.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_038947971.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_038947973.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_038947974.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_038947975.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_038947976.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129277.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129278.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129279.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129280.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129281.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129282.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129283.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129284.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129285.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129286.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129287.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129288.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129289.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_063129290.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012038.1 → NP_001012038.1 myotubularin-related protein 3

See identical proteins and their annotated locations for NP_001012038.1

Status: PROVISIONAL

Source sequence(s)

BC087045

UniProtKB/Swiss-Prot

Q5PQT2

UniProtKB/TrEMBL

A0A0G2K8C7

Related

ENSRNOP00000054309.2, ENSRNOT00000057501.3

Conserved Domains (3) summary

cd13341
Location:19 → 112

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1111 → 1171

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

pfam06602
Location:123 → 519

Myotub-related; Myotubularin-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

83564065..83684573 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273211.1 → XP_063129281.1 myotubularin-related protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I5ZTK5, A6IKG8
XM_039092046.2 → XP_038947974.1 myotubularin-related protein 3 isoform X3

UniProtKB/TrEMBL

A0A0G2K8C7, A0A8I5ZTK5, A6IKG8

Related

ENSRNOP00000082114.1

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1115 → 1175

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_006251302.5 → XP_006251364.1 myotubularin-related protein 3 isoform X1

See identical proteins and their annotated locations for XP_006251364.1

UniProtKB/TrEMBL

A0A0G2K8C7, A0A8I6AAN8

Related

ENSRNOP00000089594.1

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1115 → 1184

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_063273214.1 → XP_063129284.1 myotubularin-related protein 3 isoform X4

UniProtKB/TrEMBL

A0A8I5ZLG1
XM_063273207.1 → XP_063129277.1 myotubularin-related protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I6AAN8
XM_039092045.2 → XP_038947973.1 myotubularin-related protein 3 isoform X2

UniProtKB/TrEMBL

A0A0G2K8C7

Related

ENSRNOP00000074555.2

Conserved Domains (3) summary

cd13341
Location:19 → 112

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1111 → 1180

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:165 → 481

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_008770301.4 → XP_008768523.1 myotubularin-related protein 3 isoform X1

See identical proteins and their annotated locations for XP_008768523.1

UniProtKB/TrEMBL

A0A0G2K8C7, A0A8I6AAN8

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1115 → 1184

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_006251305.5 → XP_006251367.1 myotubularin-related protein 3 isoform X1

See identical proteins and their annotated locations for XP_006251367.1

UniProtKB/TrEMBL

A0A0G2K8C7, A0A8I6AAN8

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1115 → 1184

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_039092043.2 → XP_038947971.1 myotubularin-related protein 3 isoform X2

UniProtKB/TrEMBL

A0A0G2K8C7

Conserved Domains (3) summary

cd13341
Location:19 → 112

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1111 → 1180

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:165 → 481

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_039092042.2 → XP_038947970.1 myotubularin-related protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2K8C7, A0A8I6AAN8

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1115 → 1184

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_039092041.2 → XP_038947969.1 myotubularin-related protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2K8C7, A0A8I6AAN8

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1115 → 1184

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_006251304.5 → XP_006251366.1 myotubularin-related protein 3 isoform X1

See identical proteins and their annotated locations for XP_006251366.1

UniProtKB/TrEMBL

A0A0G2K8C7, A0A8I6AAN8

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1115 → 1184

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_039092040.2 → XP_038947968.1 myotubularin-related protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2K8C7, A0A8I6AAN8

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1115 → 1184

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_063273219.1 → XP_063129289.1 myotubularin-related protein 3 isoform X6
XM_039092047.2 → XP_038947975.1 myotubularin-related protein 3 isoform X4

UniProtKB/TrEMBL

A0A0G2K8C7, A0A8I5ZLG1

Related

ENSRNOP00000078759.1

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1078 → 1147

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_063273220.1 → XP_063129290.1 myotubularin-related protein 3 isoform X7
XM_063273218.1 → XP_063129288.1 myotubularin-related protein 3 isoform X5

UniProtKB/TrEMBL

A6IKG6
XM_063273213.1 → XP_063129283.1 myotubularin-related protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I5ZTK5, A6IKG8
XM_063273215.1 → XP_063129285.1 myotubularin-related protein 3 isoform X5

UniProtKB/TrEMBL

A6IKG6
XM_063273209.1 → XP_063129279.1 myotubularin-related protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I5ZTK5, A6IKG8
XM_063273217.1 → XP_063129287.1 myotubularin-related protein 3 isoform X5

UniProtKB/TrEMBL

A6IKG6
XM_063273212.1 → XP_063129282.1 myotubularin-related protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I5ZTK5, A6IKG8
XM_063273216.1 → XP_063129286.1 myotubularin-related protein 3 isoform X5

UniProtKB/TrEMBL

A6IKG6
XM_039092048.2 → XP_038947976.1 myotubularin-related protein 3 isoform X5

UniProtKB/TrEMBL

A0A0G2K8C7, A6IKG6

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1078 → 1138

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_063273210.1 → XP_063129280.1 myotubularin-related protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I5ZTK5, A6IKG8
XM_063273208.1 → XP_063129278.1 myotubularin-related protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I5ZTK5, A6IKG8