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    Zfp455 zinc finger protein 455 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286979, updated on 29-Feb-2024

    Summary

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    Official Symbol
    Zfp455provided by RGD
    Official Full Name
    zinc finger protein 455provided by RGD
    Primary source
    RGD:628788
    See related
    Ensembl:ENSRNOG00000031576 AllianceGenome:RGD:628788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kzf2; Kzf-2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF429 (zinc finger protein 429). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 54.9), Spleen (RPKM 48.9) and 9 other tissues See more
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    Genomic context

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    See Zfp455 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (86326568..86445514)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (84712431..84733542)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (86996775..87011696)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 708 Neighboring gene 60 kDa heat shock protein, mitochondrial-like Neighboring gene zinc finger protein 728-like Neighboring gene zinc finger protein 728-like Neighboring gene zinc finger protein 457 Neighboring gene uncharacterized LOC134485874 Neighboring gene zinc finger protein 728-like Neighboring gene zinc finger protein 458 Neighboring gene regulator of sex limited protein 1 Neighboring gene zinc finger protein 431 like 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kzf1 - a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis. Bellefroid EJ, et al. Biochim Biophys Acta, 1998 Jul 9. PMID 9655926
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 455
    Names
    KRAB-zinc finger protein KZF-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173314.2 → NP_775436.2  zinc finger protein 455

      See identical proteins and their annotated locations for NP_775436.2

      Status: VALIDATED

      Source sequence(s)
      BC161833, BM390486, U67083
      UniProtKB/TrEMBL
      A6JN15, G3V9J4
      Related
      ENSRNOP00000049638.3, ENSRNOT00000042058.6
      Conserved Domains (5) summary
      smart00349
      Location:5 → 64
      KRAB; krueppel associated box
      COG5048
      Location:107 → 458
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:389 → 409
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 44
      KRAB; KRAB box
      pfam13465
      Location:429 → 454
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      86326568..86445514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281440.1 → XP_063137510.1  zinc finger protein 455 isoform X2

    2. XM_039101864.2 → XP_038957792.1  zinc finger protein 455 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:2 → 61
      KRAB; krueppel associated box
      COG5048
      Location:104 → 455
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:386 → 406
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_063281441.1 → XP_063137511.1  zinc finger protein 455 isoform X3

    4. XM_063281439.1 → XP_063137509.1  zinc finger protein 455 isoform X1

    5. XM_063281437.1 → XP_063137507.1  zinc finger protein 455 isoform X1

    6. XM_063281438.1 → XP_063137508.1  zinc finger protein 455 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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